5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole | 850363-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole
• 英文别名: tert-butyl N-[2-[4-[2-(oxan-2-yl)-4-(1H-pyrazol-4-yl)indazol-5-yl]phenyl]propan-2-yl]carbamate
• CAS: 850363-30-3
• 化学式: C₂₉H₃₅N₅O₃
• 分子量: 501.629
• InChiKey: YIMWNQSODAJZAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-Boc-吡唑-4-硼酸频哪醇酯 、 5-[4-(1-tert-Butoxycarbonylamino-1-methylethyl)-phenyl]-2-(tetrahydropyran-2-yl)-4-trifluoromethane-sulfonyloxy-2H-indazole 在 四(三苯基膦)钯 sodium carbonate 、 甲醇 、 sodium hydroxide 、 水 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 1.0h， 以81%的产率得到5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole
  参考文献：
  名称：

  NOVEL INDAZOLE DERIVATIVE

  摘要：

  公开号：

  EP1679308B1

文献信息

• Novel indazole derivatives
  申请人：Hagihara Masahiko

  公开号：US20070129404A1

  公开（公告）日：2007-06-07

  An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R 1 and R 2 are H or alkyl; R 3 and R 4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R 5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.

  本发明的目的是创建一种新的吲唑衍生物作为药物，并找到该衍生物的新的药理作用。本发明的化合物由公式[I]表示，并具有出色的Rho激酶抑制作用。在公式中，环X是苯环或吡啶环；R1和R2是H或烷基；R3和R4是卤素，H，OH，烷氧基，烯氧基，炔氧基，环烷氧基，环烯氧基，芳氧基，烷基，烯基，炔基，环烷基，环烯基，芳基，羧基，烷基羰基等；而R5是卤素原子，H，OH，烷氧基，芳氧基，烷基或芳基。每个基团都可以被取代。
• Novel indazole derivative
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP2468729A1

  公开（公告）日：2012-06-27

  The invention relates to compounds of formula (I): in which R1, R2, R3, R4, R5 and X are as defined in the description. These compounds are useful as Rho kinase inhibitors.

  本发明涉及式 (I) 化合物： 其中 R1、R2、R3、R4、R5 和 X 如描述中所定义。这些化合物可用作 Rho 激酶抑制剂。
• Methods for treating a disease in which Rho kinase is involved
  申请人：Hagihara Masahiko

  公开号：US20090264468A1

  公开（公告）日：2009-10-22

  A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: , wherein the ring X is a benzene ring or a pyridine ring; R 1 and R 2 are hydrogen or alkyl or together form a cycloalkene ring; R 3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R 4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R 5 is a halogen atom or a hydrogen atom.
• US7563906B2
  申请人：——

  公开号：US7563906B2

  公开（公告）日：2009-07-21
• US7855222B2
  申请人：——

  公开号：US7855222B2

  公开（公告）日：2010-12-21