2-(4-phenoxyphenyl)-2,7-diazaspiro[4.5]decan-1-one hydrochloride | 852338-82-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-phenoxyphenyl)-2,7-diazaspiro[4.5]decan-1-one hydrochloride
• 英文别名: 2,7-Diazaspiro[4.5]decan-1-one, 2-(4-phenoxyphenyl)-, (Hydrochloride) (1:1)；2-(4-phenoxyphenyl)-2,9-diazaspiro[4.5]decan-1-one;hydrochloride
• CAS: 852338-82-0
• 化学式: C₂₀H₂₂N₂O₂*ClH
• 分子量: 358.868
• InChiKey: ZTMVDCQAYXLPPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.01
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  41.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HETEROCYCLIC SPIRO COMPOUND
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1683797A1

  公开（公告）日：2006-07-26

  The compound represented by formula (I) (wherein D and G are cyclic group which may have a substituent(s) or alkyl which may have a substituent(s), W and Y are a bond or a spacer of which main chain has an atom number of 1-4, ringA and ringB are heterocyclic ring which may have a substituent(s), containing at least one carbon atom and one nitrogen atom and the ringA and ringB share one spiro carbon atom.), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof Since the compounds represented by formula (I), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof have the affinity to MBR, they are useful for the prevention and/or treatment for disease caused by stress.

  公式（I）所代表的化合物（其中D和G是可能具有取代基的环族，或者是可能具有取代基的烷基，W和Y是具有1-4个原子编号的主链的键或间隔物，环A和环B是可能具有取代基的杂环，含有至少一个碳原子和一个氮原子，环A和环B共享一个螺环碳原子），其盐，N-氧化物或溶剂合物，或其前药。由于公式（I）所代表的化合物，其盐，N-氧化物或溶剂合物，或其前药对MBR具有亲和力，因此它们对于预防和/或治疗由压力引起的疾病是有用的。
• Heterocyclic Spiro Compound
  申请人：Ohmoto Kazuyuki

  公开号：US20070275990A1

  公开（公告）日：2007-11-29

  The compound represented by formula (I) (wherein D and G are cyclic group which may have a substituent(s) or alkyl which may have a substituent(s), W and Y are a bond or a spacer of which main chain has an atom number of 1-4, ringA and ringB are heterocyclic ring which may have a substituent(s), containing at least one carbon atom and one nitrogen atom and the ringA and ringB share one spiro carbon atom), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof. Since the compounds represented by formula (I), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof have the affinity to MBR, they are useful for the prevention and/or treatment for disease caused by stress.

  化合物的化学式为（I）（其中D和G是环状基团，可能有取代基或烷基，也可能有取代基；W和Y是键或间隔物，其主链具有1-4个原子数；环A和环B是杂环环，可能有取代基，含有至少一个碳原子和一个氮原子，环A和环B共享一个螺环碳原子），其盐、N-氧化物或溶剂化物，或其前药物。由于化合物（I）及其盐、N-氧化物或溶剂化物或其前药物具有对MBR的亲和力，它们对于预防和/或治疗由压力引起的疾病是有用的。