2-((5,6-dimethylpyridin-2-yl)carbamoyl)-4,5-bis(trifluoromethyl)benzoic acid | 1620997-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((5,6-dimethylpyridin-2-yl)carbamoyl)-4,5-bis(trifluoromethyl)benzoic acid
• 英文别名: 2-[(5,6-Dimethylpyridin-2-yl)carbamoyl]-4,5-bis(trifluoromethyl)benzoic acid；2-[(5,6-dimethylpyridin-2-yl)carbamoyl]-4,5-bis(trifluoromethyl)benzoic acid
• CAS: 1620997-26-3
• 化学式: C₁₇H₁₂F₆N₂O₃
• 分子量: 406.284
• InChiKey: GDSGLTVXDGBQEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS<br/>[FR] ACIDES PHTALAMIQUES N-SUBSTITUÉS-5-SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE LA SORTILINE
  申请人：LUNDBECK & CO AS H

  公开号：WO2014114779A1

  公开（公告）日：2014-07-31

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

  本发明涉及公式（A）的N-取代-5-取代邻苯二甲酰胺酸。这些化合物被认为对治疗神经退行性疾病、精神疾病、运动神经元疾病、外周神经病、疼痛、神经炎症或动脉粥样硬化等疾病的治疗有用，如阿尔茨海默病和帕金森病。
• N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：US20150368231A1

  公开（公告）日：2015-12-24

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

  本发明涉及式(A)的N-取代-5-取代邻苯二甲酸衍生物。这些化合物被认为对治疗神经退行性疾病、精神疾病、运动神经元疾病、周围神经病、疼痛、神经炎症或动脉粥样硬化疾病如阿尔茨海默病和帕金森病具有用处。
• N-substituted-5-substituted phthalamic acids as sortilin inhibitors
  申请人：H. Lundbeck A/S

  公开号：US10195186B2

  公开（公告）日：2019-02-05

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

  本发明涉及式（A）的 N-取代-5-取代酞胺酸。 这些化合物可用于治疗神经退行性疾病、精神疾病、运动神经元疾病、周围神经病、疼痛、神经炎症或动脉粥样硬化等疾病，如阿尔茨海默氏症和帕金森氏症。
• N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors
  申请人：H. Lundbeck A/S

  公开号：US20170239226A1

  公开（公告）日：2017-08-24

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.
• US9682967B2
  申请人：——

  公开号：US9682967B2

  公开（公告）日：2017-06-20