[5-（甲基亚硝基氨基）-1-（3-吡啶基）-1-戊醇 | 887407-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: [5-（甲基亚硝基氨基）-1-（3-吡啶基）-1-戊醇
• 英文名称: [5-(Methylnitrosamino)-1-(3-pyridyl)-1-pentanol
• 英文别名: N-(5-hydroxy-5-pyridin-3-ylpentyl)-N-methylnitrous amide
• CAS: 887407-09-2
• 化学式: C₁₁H₁₇N₃O₂
• 分子量: 223.27
• InChiKey: MHWBZHPAMNCSHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  437.6±40.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿、乙酸乙酯、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compositions and methods for treating nasal and paranasal mucosa diseases with nicotinic acetylcholine receptor agonists
  申请人：Solis Herrera Arturo

  公开号：US10639300B2

  公开（公告）日：2020-05-05

  Methods of treating and preventing conditions of a nasal or paranasal mucous membrane are described. The methods include administering a pharmaceutical composition including a nicotinic acetylcholine receptor (nAChR) agonist, such as (S)-(1-methyl-2-pyrrolidinyl)-pyridine, or a pharmaceutically acceptable salt, analog, precursor or derivative thereof. The methods can be used to treat a wide variety of conditions of the nasal or paranasal mucous membrane, such as nasal congestion and nose bleeds.

  本文描述了治疗和预防鼻腔或副鼻腔粘膜疾病的方法。这些方法包括施用药物组合物，其中包括烟碱乙酰胆碱受体（nAChR）激动剂，如(S)-(1-甲基-2-吡咯烷基)-吡啶，或其药学上可接受的盐、类似物、前体或衍生物。这些方法可用于治疗鼻腔或副鼻黏膜的各种疾病，如鼻塞和鼻出血。
• COMPOSITIONS AND METHODS FOR TREATING NASAL AND PARANASAL MUCOSA DISEASES WITH NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS
  申请人：SOLIS HERRERA Arturo

  公开号：US20190111038A1

  公开（公告）日：2019-04-18

  Methods of treating and preventing conditions of a nasal or paranasal mucous membrane are described. The methods include administering a pharmaceutical composition including a nicotinic acetylcholine receptor (nAChR) agonist, such as (S)-(1-methyl-2-pyrrolidinyl)-pyridine, or a pharmaceutically acceptable salt, analog, precursor or derivative thereof. The methods can be used to treat a wide variety of conditions of the nasal or paranasal mucous membrane, such as nasal congestion and nose bleeds.