(2R)-2-(methanesulfonylmethyl)pyrrolidine | 290328-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2R)-2-(methanesulfonylmethyl)pyrrolidine
• 英文别名: (2R)-2-(methylsulfonylmethyl)pyrrolidine
• CAS: 290328-58-4
• 化学式: C₆H₁₃NO₂S
• 分子量: 163.24
• InChiKey: VAVPZFZZRHYBLR-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Method of decreasing inflammation in kidney transplantion using angiotensin receptor blockers
  申请人：Becker N. Bryan

  公开号：US20050282877A1

  公开（公告）日：2005-12-22

  Disclosed is a method of inhibiting production of IFN-Γ in patients having a transplanted organ. The method involves administering to the patient an amount of an angiotensin receptor-blocking compound, the amount being effective to inhibit production of IFN-Γ by T cells. The method can be used to treat inflammation involving an allograft, to treat chronic allograft nephropathy, and to treat other pathologies associated with allograft rejection.

  本发明公开了一种抑制移植器官患者产生 IFN-Γ 的方法。该方法包括向患者施用一定量的血管紧张素受体阻断化合物，该剂量可有效抑制 T 细胞产生 IFN-Γ。该方法可用于治疗涉及同种异体移植物的炎症、治疗慢性同种异体移植物肾病以及治疗与同种异体移植物排斥相关的其他病症。
• NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF
  申请人：MERCK & CO., INC.

  公开号：EP1159263A1

  公开（公告）日：2001-12-05
• [EN] NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSES DE SULFONAMIDE ET UTILISATIONS CORRESPONDANTES
  申请人：MERCK & CO INC

  公开号：WO2000050391A1

  公开（公告）日：2000-08-31

  In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid β protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.