1-(2-Oxopentan-3-yl)pyrrolidin-2-one | 925246-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Oxopentan-3-yl)pyrrolidin-2-one
• CAS: 925246-40-8
• 化学式: C₉H₁₅NO₂
• 分子量: 169.22
• InChiKey: DYQQCZNFMAUFMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
  申请人：Ates Celal

  公开号：US20070142647A1

  公开（公告）日：2007-06-21

  The present invention relates to an improved process for the preparation of (S)-(-)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R 1 is methyl or ethyl; and R 2 is C 2 -C 4 alkyl, C 2 -C 4 alkenyl or C 2 -C 4 alkynyl, optionally substituted by one or more halogen, and their preparation processes.

  本发明涉及一种改进的方法，用于制备（S）-（-）-α-乙基-2-氧代-1-吡咯烷乙酰胺及其类似物。本发明还涉及一般式（6）中化合物的制备方法，其中R1为甲基或乙基; R2为C2-C4烷基，C2-C4烯基或C2-C4炔基，可以选择性地被一个或多个卤素取代。
• US7563912B2
  申请人：——

  公开号：US7563912B2

  公开（公告）日：2009-07-21
• [EN] REGIOSELECTIVE OXIDATION OF HETEROCYCLIC ALPHA-AMINO AMIDES<br/>[FR] OXYDATION RÉGIOSÉLECTIVE D'ALPHA-AMINO AMIDES HÉTÉROCYCLIQUES
  申请人：PHARMAZELL GMBH

  公开号：WO2021214278A2

  公开（公告）日：2021-10-28

  The present invention relates to regioselective chemical and electrochemical processes for the preparation of an oxidized heterocyclic alpha-amino amide compounds. By applying specific catalysts or catalyst systems during chemical oxidation or by applying particular electrochemical oxidation conditions the present invention provides access to valuable alpha amino amide compounds, which are oxidized at the heterocyclic amino group by regioselective introduction of either a hydroxyl or a keto group. In a more particular embodiment, the present invention describes a chemical oxidation reaction, which advantageously is applicable in the enantioselective synthesis of valuable oxidized heterocyclic alpha-amino amide compounds, like levetiracetam, brivaracetam or the synthesis of piracetam. Another aspect of the present invention relates to a process for the electrochemical recycling of alkali perhalogenate oxidants as spent during said regioselective oxidation reactions of the invention. Still another aspect of the invention relates to the electrochemical preparation of perhalogenates.