[6R-[6alpha,7beta(R*)]]-7-(氨基苯基乙酰氨基)-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸钠 | 38932-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 中文名称: [6R-[6alpha,7beta(R*)]]-7-(氨基苯基乙酰氨基)-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸钠
• 中文别名: 头孢氨苄钠
• CAS: 38932-40-0
• 化学式: C16H17N3NaO4S
• 分子量: 370.4
• InChiKey: IUQVGBBNUVMARI-CYJZLJNKSA-N

物化性质

• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.06
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• Controlled release oral drug delivery system
  申请人：The Jordanian Pharmaceutical Manufacturing Co.

  公开号：EP1721602A1

  公开（公告）日：2006-11-15

  The invention relates to a molecular ionic complex formed between an acidic pharmaceutical drug or its salt or solvate and glucosamine, chondroitin, hyaluronic acid or heparin or its salts or derivatives. The complex can provide for a liquid oral controlled drug delivery. For example, ibuprofen sodium complex with glucosamine sulfate potassium (GSP) was found to have a zero order controlled drug delivery when given orally to rabbits.

  本发明涉及一种由酸性药物或其盐或溶剂与葡萄糖胺、软骨素、透明质酸或肝素或其盐或衍生物形成的分子离子复合物。该复合物可提供液体口服控制药物释放。例如，发现当将布洛芬钠与硫酸葡萄糖胺钾（GSP）形成复合物后，口服给兔子时具有零级控制药物释放。
• Therapeutic human antipseudomonas aeruginosa antibodies
  申请人：Merck & Co., Inc.

  公开号：EP0256713A2

  公开（公告）日：1988-02-24

  Human lymphoblastoid cell lines and hybridomas are developed which secrete antibodies specifically reactive with lipopolysaccharide that is present on the surface of Pseudomonas aeruginosa. The individual monoclonal antibodies are immunospecific for one or more of the Fisher immunotypes of P. aeruginosa. The anti-Pseudomonas monoclonal anti­bodies are used individually or in combination to therapeutically or prophylactically treat P. aeruginosa infections. One or more of the monoclonal antibodies are co-administered with one or more antibiotics to therapeutically or prophylactically treat immunocompromised and immunosuppressed individuals.

  人类淋巴母细胞系和杂交瘤被开发出来，它们能分泌与铜绿假单胞菌表面的脂多糖特异性反应的抗体。单克隆抗体对铜绿假单胞菌的一种或多种费舍尔免疫型具有免疫特异性。抗铜绿假单胞菌单克隆抗体可单独或联合用于治疗或预防铜绿假单胞菌感染。一种或多种单克隆抗体可与一种或多种抗生素联合使用，用于治疗或预防免疫功能低下和免疫抑制个体。
• Method for transferring one or more active ingredients between different phase carriers
  申请人：Purzer Pharmaceutical Co., Ltd.

  公开号：EP1172099A1

  公开（公告）日：2002-01-16

  A method for transferring one or more active ingredients between different phase carriers, includes: (a) providing a solid, semi-solid, or non-aqueous liquid drug which contains at least one active ingredient; (b) admixing said drug with water or water solution to form an admixture; and (c) nebulizing said admixture to form liquid fine drops containing said active ingredient. This method enables the active ingredient stored in a solid phase carrier to transfer into an aqueous phase carrier, or enables the active ingredient stored in a non-aqueous liquid carrier to transfer into an aqueous phase carrier. The aqueous phase carrier containing the active ingredient can then be nebulized with a nebulizer by means of ultrasonic vibration. The method controls administration by transferring the active ingredient between different phase carriers.

  一种在不同相载体之间转移一种或多种活性成分的方法，包括(a) 提供含有至少一种活性成分的固体、半固体或非水相液体药物；(b) 将所述药物与水或水溶液混合，形成混合物；以及 (c) 雾化所述混合物，形成含有所述活性成分的液态微滴。这种方法可以将固相载体中的活性成分转移到水相载体中，或将非水相液体载体中的活性成分转移到水相载体中。然后，含有活性成分的水相载体可以通过超声波振动的方式用雾化器雾化。该方法通过在不同相载体之间转移活性成分来控制给药。
• γ-AApeptides with potent and broad-spectrum antimicrobial activity
  申请人：Cai Jianfeng

  公开号：US10144764B2

  公开（公告）日：2018-12-04

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一类名为γ-AA肽的新型抗菌剂。本发明提供了各种类型的 γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂化γ-AA肽。本发明中的γ-AA 肽具有抗菌活性，同时稳定无毒。γ-AA肽似乎也不会导致被处理微生物产生抗药性。因此，所公开的γ-AA 肽可用于治疗与病原微生物有关的各种病症。