N-pyridin-3-ylethanethioamide | 57416-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-pyridin-3-ylethanethioamide
• 英文别名: pyrid-3-yl-thioacetamide；N-3-Pyridinylethanethioamide
• CAS: 57416-40-7
• 化学式: C₇H₈N₂S
• 分子量: 152.22
• InChiKey: AYKUGKOZXUHCFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  57
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] AMINOPYRAZOLE COMPOUNDS AND USE AS CHK1 INHIBITORS<br/>[FR] COMPOSES D'AMINOPYRRAZOLES ET LEUR UTILISATION COMME INHIBITEURS DE LA CHK1
  申请人：PFIZER

  公开号：WO2005009435A1

  公开（公告）日：2005-02-03

  Described herein are aminopyrazole compounds of formula (I), wherein R1, R2, L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such modulation to treat cell proliferative disorders. Also described are pharmaceutical compositions containing such compounds. Also described are the therapeutic or prophylactic use of such compounds and compositions, and methods of treating cancer as well as other diseases associated with unwanted cellular proliferation, by administering effective amounts of such compounds in combination with anti-neoplastic agents.

  本文描述了式（I）的氨基吡唑化合物，其中R1、R2、L和Ar如规范中所定义。这些化合物能够调节检查点激酶的活性，并且利用这种调节方法治疗细胞增殖性疾病。还描述了含有这些化合物的药物组合物。还描述了这些化合物和组合物的治疗或预防用途，以及通过与抗肿瘤药物联合给予这些化合物的有效量来治疗癌症以及其他与不必要细胞增殖相关的疾病的方法。
• Aminopyrazole compounds
  申请人：Johnson David Michael

  公开号：US20050043381A1

  公开（公告）日：2005-02-24

  Described herein are aminopyrazole compounds of formula I: wherein R 1 , R 2 , L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such modulation to treat cell proliferative disorders. Also described are pharmaceutical compositions containing such compounds. Also described are the therapeutic or prophylactic use of such compounds and compositions, and methods of treating cancer as well as other diseases associated with unwanted cellular proliferation, by administering effective amounts of such compounds in combination with anti-neoplastic agents.

  本文介绍了公式I的氨基吡唑化合物：其中R1，R2，L和Ar如规范中所定义。这些化合物能够调节检查点激酶的活性，并利用这种调节方法治疗细胞增殖性疾病。还描述了包含这些化合物的药物组合物。还描述了这些化合物和组合物的治疗或预防用途，以及通过与抗肿瘤剂联合给予这些化合物的有效量来治疗癌症以及与不必要的细胞增殖有关的其他疾病的方法。
• HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS
  申请人：Kshirsagar Tushar A.

  公开号：US20090221556A1

  公开（公告）日：2009-09-03

  1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本文介绍了在2位置具有羟基，烷氧基，羟基烷氧基或烷氧基烷氧基取代基的1H-咪唑并[4,5-c]喹啉-4-胺类化合物、含有这些化合物的制药组合物、制备这些化合物的方法、中间体以及这些化合物作为免疫调节剂的用途，用于诱导动物细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
• Aryloxy and Arylalkyleneoxy Substituted Imidazoquinolines
  申请人：Lindstrom Kyle J.

  公开号：US20090018122A1

  公开（公告）日：2009-01-15

  Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本发明涉及一种咪唑喹啉化合物，其在6、7、8或9位具有芳氧基，芳基烷氧基或羟基取代基，以及含有该化合物的制药组合物，中间体和使用这些化合物作为免疫调节剂的方法，用于调节动物中的细胞因子生物合成，并用于治疗包括病毒性和肿瘤性疾病在内的疾病。
• PYRAZOLOPYRIDINES AND ANALOGS THEREOF
  申请人：Hays David S.

  公开号：US20090318435A1

  公开（公告）日：2009-12-24

  Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本文介绍了吡唑吡啶-4-胺，吡唑喹啉-4-胺，吡唑萘啉-4-胺和6,7,8,9-四氢吡唑喹啉-4-胺，含有这些化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物细胞因子生物合成，以及用于治疗包括病毒和肿瘤疾病在内的疾病。