(4-Nitrophenyl)-dioxido-oxo-lambda5-phosphane | 111192-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Nitrophenyl)-dioxido-oxo-lambda5-phosphane
• 英文别名: (4-nitrophenyl)-dioxido-oxo-λ5-phosphane
• CAS: 111192-86-0
• 化学式: C₆H₄NO₅P
• 分子量: 201.075
• InChiKey: CBWCNKVANCTCAD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  vanadia 、 (4-Nitrophenyl)-dioxido-oxo-lambda5-phosphane 以 水 为溶剂， 生成
  参考文献：
  名称：

  Toward Prediction of Magnetic Properties in Layered Vanadyl Phosphonates:  Correlation of Magnetic Exchange with the Hammett σ Parameter

  摘要：

  The magnetic properties of the layered vanadyl phosphonates (LVPs) VO(O3PC6H4-X).nH2O (X = p-NO2, m-F, p-Cl, p-F, H, p-CH3) have been investigated. In the isostructural n = 1 series (X = p-NO2, m-F, p-F, H), the paramagnetic d(1) vanadyl centers are coupled via the O-P-O pathways of V(OPO)(2)V chair-like subunits. The magnetic properties of these LVPs can be systematically controlled by modification of the P atom's electronic environment via variations of the X group in the aryl pendant. The simple paramagnetism of the LVP featuring the strong electron withdrawing substituent X = p-NO2 gives way to increasing antiferromagnetic coupling between the V-IV centers as the electron-donating ability of X is increased. Consistent with a chair-like V(OPO)(2)V exchange pathway between pairs of vanadyl centers, the temperature-dependent magnetic susceptibility data fit a Bleaney-Bowers dimer model. When the substituent is large, as is the case for the p-Cl and p-CH3 species, a structurally different class of LVPs is obtained, in which n = 1.5. In this case, the contribution of the O-P-O linkage is overwhelmed by the presence of the more direct exchange pathway of vanadyl centers through mu(2)-bridging oxygens of a V(mu(2)-O)(2)V dimer, obviating the effects of electronic variations in Be phosphonate bridge. Our results show that magnetic coupling correlates with a simple measure of electronic perturbation of the exchange pathway in LVPs, implying that such interactions can be tuned using the traditional tools of physical organic chemistry.

  DOI：

  10.1021/ja9624836

文献信息

• [EN] METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES<br/>[FR] ARYLATION DIRECTE SANS MÉTAL DE PHOSPHONATES DE DIALKYLE POUR LA SYNTHÈSE DE PHOSPHONATES D'ARYLE ALKYLE MIXTES
  申请人：THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE

  公开号：WO2019028391A1

  公开（公告）日：2019-02-07

  Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文提供了磷酸盐、硫代磷酸盐、膦酸盐和膦酸盐，以及制备这些化合物的方法，以及使用这些化合物和用于生成与药用相关的磷酸盐、膦酸盐和膦酸盐类似物的方法。此摘要旨在作为搜索特定领域的扫描工具，并不限制本发明。
• AMINO PYRIMIDINE ANTICANCER COMPOUNDS
  申请人：OSI PHARMACEUTICALS, LLC

  公开号：US20130231306A1

  公开（公告）日：2013-09-05

  Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

  化学式为1的化合物，如下所示并在此定义：以及药学上可接受的盐，合成方法，中间体，制剂和治疗疾病的方法，包括至少部分由FAK介导的癌症。
• Methods and compositions for polypeptide engineering
  申请人：Maxygen, Inc.

  公开号：EP1149905A1

  公开（公告）日：2001-10-31

  Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting combination and selection. Compositions produced by these methods are also disclosed.

  本研究提供了用于工业和制药业蛋白质进化的方法，包括进行组合和选择的方法。此外，还公开了通过这些方法生产的合成物。
• Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates
  申请人：The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada, Las Vegas

  公开号：US10927135B2

  公开（公告）日：2021-02-23

  Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明提供了磷酸盐、硫代磷酸盐、膦酸盐和膦酸盐、其制造方法、使用这些化合物的方法以及生成药用磷酸盐、膦酸盐和膦酸盐类似物的方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• INTERACTION SYSTEM COMPRISING A SURFACTANT-STABILIZED DISPERSE AQUEOUS PHASE CONTAINING AN ANTIBODY OR ANTIBODY FRAGMENT
  申请人：IGEN, INCORPORATED

  公开号：EP0414755A1

  公开（公告）日：1991-03-06