1-(12,14-Dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)-2,5-diphenylpyrrolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(12,14-Dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)-2,5-diphenylpyrrolidine
• 化学式: C₃₆H₂₈NO₂P
• 分子量: 537.6
• InChiKey: SQEYSQAZYNQDSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PHOSPHORAMIDITE LIGAND AND PRODUCTION METHOD OF ALLYLIC AMINE USING THE SAME
  申请人：CARREIRA Erick M.

  公开号：US20090054689A1

  公开（公告）日：2009-02-26

  The present invention provides a production method of an allylic amine represented by the formula (III): wherein R 3 is as defined in the specification, which comprises reacting by an allylic alcohol represented by the formula (II): wherein R 3 is as defined in the specification, with sulfamic acid, in the presence of a phosphoramidite ligand represented by the formula (I): wherein each symbol is as defined in the specification, and an iridium complex. According to the present invention, a primary allylic amine can be produced directly from an allylic alcohol, without use of an activator for an allylic alcohol and conversion of an allylic alcohol into an activated compound thereof.

  本发明提供了一种制备烯丙胺的生产方法，烯丙胺的化学式为(III)，其中R3如规范中定义，该方法包括使用磷酰胺配体(I)和铱配合物，在磺酸的存在下，将烯丙醇(II)与磺酸反应。根据本发明，可以直接从烯丙醇中生产出主要的烯丙胺，而无需使用烯丙醇的活化剂，也无需将烯丙醇转化为其活化化合物。
• US7863443B2
  申请人：——

  公开号：US7863443B2

  公开（公告）日：2011-01-04