Eprinomectin B1b | 133305-89-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: Eprinomectin B1b
• 英文别名: N-[(2S,3R,4S,6S)-6-[(2S,3S,4S,6R)-6-[(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-3,11',13',22'-tetramethyl-2'-oxo-2-propan-2-ylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-12'-yl]oxy-4-methoxy-2-methyloxan-3-yl]oxy-4-methoxy-2-methyloxan-3-yl]acetamide
• CAS: 133305-89-2
• 化学式: C₄₉H₇₃NO₁₄
• 分子量: 900.1
• InChiKey: WPNHOHPRXXCPRA-FZTOWWROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  64
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  179
• 氢给体数：
  3
• 氢受体数：
  14

文献信息

• Synergistic Combination of Glutamate-and Gaba-Gated Chloride Agonist Pesticide and at Least One Vitamin E, Niacin, or Derivatives Thereof
  申请人：Pedersen Morten

  公开号：US20090111759A1

  公开（公告）日：2009-04-30

  Presented are pesticidal compositions comprising at least one pesticide selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one synergist which is selected among Vitamin E, Niacin and derivatives thereof. The combinations of these compounds show a synergistic effect allowing a composition to be prepared comprising a lesser amount of pesticide, while still controlling the harmful pests.

  提供的是杀虫组合物，包括至少一种从谷氨酸或GABA门控氯离子通道激动剂杀虫剂中选择的杀虫剂，以及至少一种从维生素E、烟酸及其衍生物中选择的协同剂。这些化合物的组合表现出协同效应，允许制备含较少杀虫剂的组合物，同时仍然控制有害的害虫。
• Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
  申请人：Cheminova A/S

  公开号：EP1849363A1

  公开（公告）日：2007-10-31

  Presented are pesticidal compositions comprising at least one compound A selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one compound B which is selected among Vitamin E and Niacin. The combinations of these compounds show a synergistic effect in the control of harmful pests.

  所介绍的杀虫组合物包含至少一种选自谷氨酸或 GABA 门控氯离子通道激动剂杀虫剂的化合物 A 和至少一种选自维生素 E 和烟酸的化合物 B。这些化合物的组合在控制有害害虫方面显示出协同效应。
• Pesticidal compositions
  申请人：Cheminova A/S

  公开号：EP2033518A1

  公开（公告）日：2009-03-11

  Presented are pesticidal compositions comprising at least one pesticide selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one synergist which is selected among long chain alcohols. The combinations of these compounds show a synergistic effect allowing a composition to be prepared comprising a lesser amount of pesticide, while still controlling the harmful pests.

  所介绍的杀虫组合物包含至少一种从谷氨酸或 GABA 门控氯离子通道激动剂杀虫剂中选出的杀虫剂和至少一种从长链醇中选出的增效剂。这些化合物的组合显示出协同增效作用，从而可以制备出含有较少杀虫剂的组合物，同时仍能控制有害害虫。
• Eprinomectin parenteral compositions
  申请人：Ceva Sante Animale

  公开号：EP3023092A1

  公开（公告）日：2016-05-25

  The invention relates to a parenteral composition, wherein the formulation comprises eprinomectin and a vehicle comprising dimethylsulfoxide. It also relates to said composition for use in the treatment of infections caused by ectoparasites and endoparasites.

  本发明涉及一种肠外组合物，其中制剂包括依普瑞菌素和由二甲基亚砜组成的载体。本发明还涉及用于治疗由体外寄生虫和体内寄生虫引起的感染的上述组合物。
• Product to combat ticks and the process for the product's preparation
  申请人：Wolff Aken Bruce Zbig

  公开号：US20050118222A1

  公开（公告）日：2005-06-02

  The object of the invention of this patent is a new product and the method for its manufacturing, intended for the world's veterinary market, especially for those regions infested by ticks. Its main activity consists of simultaneously carrying, by means of an injection, a state of the art macrocyclic lactone and an antigen against ticks. The main advantage of the product consists of the reduction of the drug dose on account of its injectable presentation, without it being affected by the problems associated to the external use presentation. Moreover, the drug is a slow release drug, which allows the existence of longer intervals between applications. Finally, the product's continuous use will generate a specific immunity against ticks, thus controlling the plague in rural premises.

  本专利的发明目标是一种新产品及其制造方法，面向全球兽医市场，尤其是蜱虫肆虐的地区。它的主要作用是通过注射的方式，同时携带一种最先进的大环内酯和一种抗蜱抗原。该产品的主要优点是通过注射方式减少药物剂量，而不会受到外用药相关问题的影响。此外，该药物是一种缓释药物，可以延长用药间隔时间。最后，该产品的持续使用会对蜱产生特异性免疫，从而控制农村地区的鼠疫。