2-(Butanoyloxy)-N,N,N-trimethylethan-1-aminium 4-methylbenzene-1-sulfonate | 1866-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Butanoyloxy)-N,N,N-trimethylethan-1-aminium 4-methylbenzene-1-sulfonate
• 英文别名: 2-butanoyloxyethyl(trimethyl)azanium;4-methylbenzenesulfonate
• CAS: 1866-14-4
• 化学式: C16H27NO5S
• 分子量: 345.5
• InChiKey: DZSWXVDFVYXLHS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.94
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  91.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• SAMPLE FIXATION AND STABILISATION
  申请人：Goldsborough Andrew Simon

  公开号：US20140295404A1

  公开（公告）日：2014-10-02

  It has surprisingly been discovered that it is possible to stabilise biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilise and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.

  令人惊讶地发现，使用深共熔溶剂（DES）可以稳定生物样本中的生物分子，如RNA、DNA和蛋白质，例如细胞、组织、活检和血液。同时，也发现DES混合物可以用于固定和保护生物样本中的细胞形态，例如组织块、癌症活检和全血。本发明描述了使用DES混合物稳定和保护生物分子、整个细胞、组织、血液和生物样本的方法。
• Sample fixation and stabilisation
  申请人：RNASSIST LTD.

  公开号：US10393633B2

  公开（公告）日：2019-08-27

  It has surprisingly been discovered that it is possible to stabilize biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilize and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.

  人们惊奇地发现，使用深共晶溶剂（DES）可以稳定细胞、组织、活检组织和血液等生物样本中的 RNA、DNA 和蛋白质等生物大分子。人们还发现，DES 混合物可用于固定和保存生物样本（如组织块、癌症活检组织和全血）中的细胞形态。本发明介绍了使用 DES 混合物稳定和保存生物分子、全细胞、组织、血液和生物样本的方法。
• PYROLYSEVERFAHREN ZUR HERSTELLUNG VON MINDESTENS EINE METALLSPEZIES AUFWEISENDEN PARTIKELN
  申请人：Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V.

  公开号：EP3294452A1

  公开（公告）日：2018-03-21
• SIMPLE FIXATION AND STABLISATION
  申请人：RNASSIST LTD.

  公开号：US20200225128A1

  公开（公告）日：2020-07-16

  It has surprisingly been discovered that it is possible to stabilise biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilise and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.
• DISSOCIATION OF BIOLOGICAL SAMPLES
  申请人：GOLDSBOROUGH Andrew Simon

  公开号：US20210231538A1

  公开（公告）日：2021-07-29

  A method of processing a biological sample to obtain single cells and/or groups of cells comprises: fixing cells of the biological sample using a fixative; contacting the biological sample with a dissociation medium; dissociating the biological sample in the presence of the dissociation medium to obtain the single cells and/or groups of cells; wherein the fixative comprises a deep eutectic solvent. Fixing cells of the biological sample using a deep eutectic solvent facilitates dissociation of the biological sample into single cells, while at the same time inhibiting the degradation of biomolecules such as DNA and RNA in the cells. Also provided is an apparatus useful in the method, deep eutectic solvents and uses thereof, and a method of extracting cell nuclei.