1-(3,7-Dimethoxyisoquinoline, hydrochloride | 36455-58-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(3,7-Dimethoxyisoquinoline, hydrochloride
• 英文别名: 1-(3,4-dimethoxyphenyl)-6,7-dimethoxyisoquinoline;hydrochloride
• CAS: 36455-58-0
• 化学式: C19H20ClNO4
• 分子量: 361.8
• InChiKey: SYXCFGWKVCJMTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.36
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Cardiomyocyte maturation
  申请人：Ncardia B.V.

  公开号：US10844354B2

  公开（公告）日：2020-11-24

  This disclosure generally concerns the fields of cell biology and molecular biology. In particular the invention concerns the field of stem cell biology and maturation of stem cell-derived cardiomyocytes. Disclosed is a method for improving the maturity of stem-cell derived cardiomyocytes, in particular of the ventricular type, as can be witnessed by, for example, an improved upstroke velocity of the stem-cell derived cardiomyocytes.

  本发明一般涉及细胞生物学和分子生物学领域。本发明尤其涉及干细胞生物学和干细胞衍生心肌细胞成熟领域。本发明公开了一种改善干细胞衍生心肌细胞（尤其是心室型）成熟度的方法，例如，干细胞衍生心肌细胞的上冲速度得到改善。
• COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS
  申请人：NeuroNova AB

  公开号：EP1583541B1

  公开（公告）日：2011-01-12
• CARDIOMYOCYTE MATURATION
  申请人：Pluriomics B.v.

  公开号：EP3152300A1

  公开（公告）日：2017-04-12
• Compounds and methods for increasing neurogenesis
  申请人：Bertilsson Goran

  公开号：US20050009847A1

  公开（公告）日：2005-01-13

  The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca 2+ elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.
• Novel cell-based phosphodiesterase assays
  申请人：Lu Jianming

  公开号：US20070224645A1

  公开（公告）日：2007-09-27

  The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds.