[甲氧基(苯基)磷酰基]甲醇 | 64128-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [甲氧基(苯基)磷酰基]甲醇
• 英文名称: methyl hydroxymethanephenylphosphinate
• 英文别名: Phosphinic acid, (hydroxymethyl)phenyl-, methyl ester；[methoxy(phenyl)phosphoryl]methanol
• CAS: 64128-97-8
• 化学式: C₈H₁₁O₃P
• 分子量: 186.147
• InChiKey: PHBSZQDIHGVTSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [甲氧基(苯基)磷酰基]甲醇 生成 methyl hydroxymethanephenylphosphinate
  参考文献：
  名称：

  Lipase-promoted kinetic resolution of racemic, P-chiral hydroxymethylphosphonates and phosphinates

  摘要：

  Lipase-mediated acetylation of racemic P-chiral hydroxymethylphosphonates and phosphinates, and hydrolysis of their O-acetyl derivatives have been conducted under kinetic resolution conditions to give the enantiomerically enriched title products with up to 92% ee. Their absolute configuration has been determined by means of chemical correlation and CD measurements. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00331-0
• 作为产物：
  描述：

  ethyl Phenylphosphinate 在 氯化铵 作用下， 以 乙醚 为溶剂， 生成 [甲氧基(苯基)磷酰基]甲醇
  参考文献：
  名称：

  Grapov,A.F. et al., Journal of general chemistry of the USSR, 1977, vol. 47, p. 1347 - 1349

  摘要：

  DOI：

文献信息

• Enzymatic reactions in ionic liquids: lipase-catalysed kinetic resolution of racemic, P -chiral hydroxymethanephosphinates and hydroxymethylphosphine oxides
  作者：Piotr Kiełbasiński、Małgorzata Albrycht、Jerzy Łuczak、Marian Mikołajczyk

  DOI：10.1016/s0957-4166(02)00167-2

  日期：2002.5

  Lipase-mediated acetylation of racemic P-chiral hydroxymethanephosphinates and hydroxymethylphosphine oxides was performed in ionic liquids under kinetic resolution conditions. Lipase AK (Amano) and lipase from Pseudomonas fluorescens (Fluka) were up to six times more enantioselective in BMIM-PF6, solutions than in common organic solvents. On the contrary, the analogous reactions performed in BMIM-BF4, were practically non-stereoselective. (C) 2002 Published by Elsevier Science Ltd.