N-[(4-bromophenyl)methyl]-1-(2,4-difluoro-6-methylphenyl)methanimine | 1002975-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4-bromophenyl)methyl]-1-(2,4-difluoro-6-methylphenyl)methanimine
• CAS: 1002975-80-5
• 化学式: C₁₅H₁₂BrF₂N
• 分子量: 324.168
• InChiKey: UHMGSMLJCLHSPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-[(4-bromophenyl)methyl]-1-(2,4,6-trifluorophenyl)methanimine 、 Dimethylzinc 在 dichlorobis(dimethylsulfide)platinum(II) 作用下， 以 氘代乙腈 为溶剂， 反应 14.0h， 以95%的产率得到N-[(4-bromophenyl)methyl]-1-(2,4-difluoro-6-methylphenyl)methanimine
  参考文献：
  名称：

  Pt(II)Cl2(DMSO)2-catalyzed cross-coupling of polyfluoroaryl imines

  摘要：

  PtCl2(DMSO)(2) has been identified as a readily accessible and effective C-F activation precatalyst We report herein the study of reaction optimization and substrate scope A comparison is made with previously reported [Pt2Me4(SMe2)(2)] and PtCl2(SMe2)(2) precatalysts (C) 2010 Elsevier B V All rights reserved

  DOI：

  10.1016/j.jfluchem.2010.06.018

文献信息

• Pt(II)Cl2(DMSO)2-catalyzed cross-coupling of polyfluoroaryl imines
  作者：Alex D. Sun、Jennifer A. Love

  DOI：10.1016/j.jfluchem.2010.06.018

  日期：2010.11

  PtCl2(DMSO)(2) has been identified as a readily accessible and effective C-F activation precatalyst We report herein the study of reaction optimization and substrate scope A comparison is made with previously reported [Pt2Me4(SMe2)(2)] and PtCl2(SMe2)(2) precatalysts (C) 2010 Elsevier B V All rights reserved