PC(P-18:0/20:4(5Z,8Z,11Z,14Z)) | 97802-56-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: PC(P-18:0/20:4(5Z,8Z,11Z,14Z))
• 英文别名: [(2R)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy-3-[(Z)-octadec-1-enoxy]propyl] 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 97802-56-7
• 化学式: C46H84NO7P
• 分子量: 794.1
• InChiKey: FHHVIBPVBBRLOR-IYACIECVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  55
• 可旋转键数：
  41
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  94.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Novel neutral (bio)material
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP2444464A1

  公开（公告）日：2012-04-25

  The instant invention concerns - a method for preparing a material comprising the following steps of a) treating the support to obtain a layer having SiH function, b) grafting the SiH layer obtained in step a) with an alkene and a catalyst for covalently bonding the alkene to the coating, said alkene being non-terminal and/or having an hydrophilic part, and c) recovering a material comprising a support coated with a chain covalently grafted with Si-C bonds, - a material comprising a support, optionally comprising a polyhydrosiloxane layer, on which surface is covalently bonded a grafted chain, wherein the covalent bonding between the support and/or the polyhydrosiloxane and the chain is an Si-C bond, and the grafted chain is bonded through a non-terminal carbon, through more than one covalent bond and/or the chain is having at least one hydrophilic part, and - devices comprising such material.

  本发明涉及 - 一种制备材料的方法，包括以下步骤 a) 处理支持物以获得具有 SiH 功能的层；b) 将步骤 a) 中获得的 SiH 层与烯烃和催化剂接枝，以将烯烃共价键合到涂层上，所述烯烃为非末端烯烃和/或具有亲水部分；以及 c) 回收一种材料，该材料包括涂有共价键合的 Si-C 键接枝链的支持物、 - 一种材料，包括支撑体，可选择包括聚氢硅氧烷层，在支撑体表面共价键合了一条接枝链，其中支撑体和/或聚氢硅氧烷与链之间的共价键合是 Si-C 键，接枝链通过非末端碳键、通过一个以上的共价键和/或链具有至少一个亲水部分键合，以及 - 包括这种材料的装置。
• MICROFLUIDIC PRODUCTION OF BIOFUNCTIONALIZED GIANT UNILAMELLAR VESICLES FOR TARGETED INTRACELLULAR CARGO DELIVERY
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3838266A1

  公开（公告）日：2021-06-23

  The present invention relates to a method for preparation of monodisperse cell-targeting giant unilamellar vesicles based on symmetrically division of a parent polymer shell-stabilized giant unilamellar vesicle into smaller polymer shell-stabilized giant unilamellar vesicles with a diameter smaller than 10 µm using a microfluidic splitting device. The inventive method allows preparation of differently charged giant unilamellar vesicles as well as bioligand- and PEG-conjugated giant unilamellar vesicles, which are useful for targeted cellular delivery at high efficiency and specificity. A further advantage of the present invention is that the giant unilamellar vesicles can deliver huge cargos such as drug releasing porous microparticles, high amounts of in vivo imaging probes, viruses, or up-and-coming DNA origami robots.

  本发明涉及一种制备单分散细胞靶向巨型单拉美米尔囊泡的方法，其基础是利用微流体分割装置将母体聚合物壳稳定巨型单拉美米尔囊泡对称分割成直径小于10微米的较小聚合物壳稳定巨型单拉美米尔囊泡。 本发明的方法可制备不同电荷的巨型单拉米分子囊泡以及生物配体和 PEG 共轭巨型单拉米分子囊泡，这些囊泡可用于高效、特异性的细胞靶向递送。本发明的另一个优点是，巨型单拉美拉尔囊泡可以输送巨大的载体，如释放药物的多孔微颗粒、大量的体内成像探针、病毒或新兴的 DNA 折纸机器人。
• BOTTOM-UP ASSEMBLY OF SYNTHETIC EXTRACELLULAR VESICLES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3858332A1

  公开（公告）日：2021-08-04

  The present invention relates to a method for producing synthetic extracellular vesicles comprising a lipid bilayer including at least two lipids, optionally one or more extracellular vesicle associated proteins, and optionally one or more nucleic acid molecules. The inventive synthetic extracellular vesicles are formed by emulsification using a mechanic emulsifier in the form of polymer shell stabilized synthetic extracellular vesicles. The inventive method allows producing synthetic extracellular vesicles miming the composition and function of natural extracellular vesicles. Therefore, synthetic extracellular vesicles with specific protein and nucleic acids compositions are also disclosed herein, as well as their therapeutic uses.

  本发明涉及一种生产合成细胞外囊泡的方法，该囊泡包括一个脂质双分子层，其中至少包括两种脂质、一种或多种细胞外囊泡相关蛋白，以及一种或多种核酸分子。本发明的合成细胞外囊泡是通过使用机械乳化剂乳化形成的聚合物壳稳定合成细胞外囊泡。本发明的方法可以生产出模拟天然细胞外囊泡成分和功能的合成细胞外囊泡。因此，本文还公开了具有特定蛋白质和核酸成分的合成细胞外囊泡及其治疗用途。
• Liposomal formulation of nonglycosidic ceramides and uses thereof
  申请人：LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.

  公开号：US10039715B2

  公开（公告）日：2018-08-07

  The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.

  本发明提供了在其双层内含有非糖苷类神经酰胺的脂质体及其组合物。这些脂质体可在体外和体内激活小鼠 iNKT 细胞并诱导树突状细胞（DC）成熟，其功效与相应的可溶性非糖苷神经酰胺相当。此外，还提供了使用本发明脂质体和组合物治疗疾病的方法。
• LIPOSOMAL FORMULATION OF NONGLYCOSIDIC CERAMIDES AND USES THEREOF
  申请人：Ludwig Institute for Cancer Research, Ltd.

  公开号：EP2654779A1

  公开（公告）日：2013-10-30