(4-(sec-Butoxy)phenyl)methanamine | 37806-45-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-(sec-Butoxy)phenyl)methanamine
• 英文别名: (4-butan-2-yloxyphenyl)methanamine
• CAS: 37806-45-4
• 化学式: C₁₁H₁₇NO
• 分子量: 179.26
• InChiKey: VXHRYPZJJPDUDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL AGENT<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN AGENT PHARMACEUTIQUE
  申请人：ZAKL FARMACEUTYCZNE POLPHARMA S A

  公开号：WO2020212268A1

  公开（公告）日：2020-10-22

  This invention relates to a process for the preparation of pimavanserin comprising: (i) providing an acid addition salt of pimavanserin; (ii) dissolving the acid addition salt of pimavanserin in an aqueous solvent to form an aqueous solution; (ill) washing the aqueous solution obtained in step (ii) with an organic solvent; and (iv) adding a base to the washed aqueous solution to form pimavanserin. The invention also relates to a process for the preparation of an acid addition salt of pimavanserin additionally comprising step (v) of converting pimavanserin into an acid addition salt of pimavanserin. The invention also relates to pimavanserin or an acid addition salt thereof obtainable by the process, and to the use of pimavanserin hydrochloride, pimavanserin hydrogen sulfate or pimavanserin acetate for preparing pimavanserin or an acid addition salt thereof.

  本发明涉及一种制备匹马万辛的方法，包括：（i）提供匹马万辛的酸盐加合物；（ii）将匹马万辛的酸盐加合物溶解在水溶剂中形成水溶液；（iii）用有机溶剂洗涤步骤（ii）中获得的水溶液；以及（iv）向洗涤后的水溶液中加入碱以形成匹马万辛。本发明还涉及一种制备匹马万辛的酸盐加合物的方法，还包括将匹马万辛转化为匹马万辛的酸盐加合物的步骤（v）。本发明还涉及通过该方法获得的匹马万辛或其酸盐加合物，以及使用匹马万辛盐酸盐、匹马万辛硫酸氢盐或匹马万辛醋酸盐制备匹马万辛或其酸盐加合物的用途。
• PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL AGENT
  申请人：Zaklady Farmaceutyczne "Polpharma" S.A.

  公开号：EP3725774A1

  公开（公告）日：2020-10-21

  This invention relates to a process for the preparation of pimavanserin comprising: (i) providing an acid addition salt of pimavanserin; (ii) dissolving the acid addition salt of pimavanserin in an aqueous solvent to form an aqueous solution; (iii) washing the aqueous solution obtained in step (ii) with an organic solvent; and (iv) adding a base to the washed aqueous solution to form pimavanserin. The invention also relates to a process for the preparation of an acid addition salt of pimavanserin additionally comprising step (v) of converting pimavanserin into an acid addition salt of pimavanserin. The invention also relates to pimavanserin or an acid addition salt thereof obtainable by the process, and to the use of pimavanserin hydrochloride, pimavanserin hydrogen sulfate or pimavanserin acetate for preparing pimavanserin or an acid addition salt thereof.

  本发明涉及一种制备pimavanserin的工艺，包括：(i)提供pimavanserin的酸加成盐；(ii)将pimavanserin的酸加成盐溶解在水性溶剂中形成水溶液；(iii)用有机溶剂洗涤步骤(ii)中得到的水溶液；以及(iv)向洗涤后的水溶液中加入碱形成pimavanserin。本发明还涉及一种制备匹马色林的酸加成盐的工艺，该工艺还包括将匹马色林转化为匹马色林的酸加成盐的步骤(v)。 本发明还涉及可通过该工艺获得的匹马伐林或其酸加成盐，以及使用盐酸匹马伐林、硫酸氢匹马伐林或醋酸匹马伐林制备匹马伐林或其酸加成盐。
• PROCESS FOR THE PREPARATION OF PHARMACEUTICAL AGENT
  申请人：ZAKLADY FARMACEUTYCZNE POLPHARMA S.A.

  公开号：US20220033356A1

  公开（公告）日：2022-02-03

  This invention relates to a process for the preparation of pimavanserin comprising: (i) providing an acid addition salt of pimavanserin; (ii) dissolving the acid addition salt of pimavanserin in an aqueous solvent to form an aqueous solution; (iii) washing the aqueous solution obtained in step (ii) with an organic solvent; and (iv) adding a base to the washed aqueous solution to form pimavanserin. The invention also relates to a process for the preparation of an acid addition salt of pimavanserin additionally comprising step (v) of converting pimavanserin into an acid addition salt of pimavanserin. The invention also relates to pimavanserin or an acid addition salt thereof obtainable by the process, and to the use of pimavanserin hydrochloride, pimavanserin hydrogen sulfate or pimavanserin acetate for preparing pimavanserin or an acid addition salt thereof.