Losartan potassium and hydrochlorothiazide | 156154-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Losartan potassium and hydrochlorothiazide
• 英文别名: potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
• CAS: 156154-37-9
• 化学式: C29H30Cl2KN9O5S2
• 分子量: 758.7
• InChiKey: XRKMYXDEMOEFBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.55
• 重原子数：
  48
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  213
• 氢给体数：
  4
• 氢受体数：
  13

文献信息

• NOVEL IMIDAZOPYRIDINE COMPOUND
  申请人：Takeuchi Jun

  公开号：US20120094944A1

  公开（公告）日：2012-04-19

  For the prevention and/or treatment of chymase-mediated diseases such as skin diseases, circulatory diseases, digestive system diseases, respiratory diseases, liver diseases, ocular diseases or the like, a drug is provided having as an active ingredient a compound having extremely strong chymase inhibitory activity, high safety, and high metabolic stability. The compound represented by the formula (I): wherein all symbols have the same meanings as in the description, a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof, is useful as a pharmaceutical ingredient having chymase inhibitory activity for preventing and/or treating of chymase-mediated disease, such as skin diseases, circulatory diseases, digestive system diseases, respiratory diseases, liver diseases, ocular diseases or the like.

  为了预防和/或治疗由钳切酶介导的疾病，如皮肤疾病、循环系统疾病、消化系统疾病、呼吸系统疾病、肝脏疾病、眼部疾病等，提供了一种药物，其活性成分是具有极强的钳切酶抑制活性、高安全性和高代谢稳定性的化合物。该化合物由以下式子表示：其中所有符号的含义与描述中相同，其盐、N-氧化物或溶剂化物，或其前药形式，可用作具有钳切酶抑制活性的药用成分，用于预防和/或治疗由钳切酶介导的疾病，如皮肤疾病、循环系统疾病、消化系统疾病、呼吸系统疾病、肝脏疾病、眼部疾病等。
• DETECTION METHOD FOR N-NITROSODIMETHYLAMINE IMPURITIES
  申请人：Zhejiang Huahai Pharmaceutical Co., Ltd.

  公开号：EP3819634A1

  公开（公告）日：2021-05-12

  Disclosed is a detection method for N-nitrosodimethylamine (NDMA) impurities, comprising: (1) obtaining a test solution containing a sample to be tested; and (2) detecting the test solution by means of gas chromatography-mass spectrometry to determine the content of an N-nitrosodimethylamine impurity in the sample. The method provided in the present invention has a good separating effect, a wide linear range, a high sensitivity and a good method durability, and can detect the content of N-nitrosodimethylamine (NDMA) in the sample rapidly and effectively.

  本发明公开了一种N-亚硝基二甲胺(NDMA)杂质的检测方法，包括：(1)获得含有待测样品的检测溶液；(2)通过气相色谱-质谱联用技术检测样品中N-亚硝基二甲胺杂质的含量。本发明提供的方法分离效果好、线性范围宽、灵敏度高、方法持久性好，能够快速有效地检测样品中 N-亚硝基二甲胺（NDMA）的含量。
• Detection method for n-nitrosodimethylamine impurities
  申请人：Zhejiang Huahai Pharmaceutical Co., Ltd

  公开号：US11519890B2

  公开（公告）日：2022-12-06

  Disclosed is a detection method for N-nitrosodimethylamine (NDMA) impurities, comprising: (1) obtaining a test solution containing a sample to be tested; and (2) detecting the test solution by means of gas chromatography-mass spectrometry to determine the content of an N-nitrosodimethylamine impurity in the sample. The method provided in the present invention has a good separating effect, a wide linear range, a high sensitivity and a good method durability, and can detect the content of N-nitrosodimethylamine (NDMA) in the sample rapidly and effectively.

  本发明公开了一种N-亚硝基二甲胺(NDMA)杂质的检测方法，包括：(1)获得含有待测样品的检测溶液；(2)通过气相色谱-质谱联用技术检测样品中N-亚硝基二甲胺杂质的含量。本发明提供的方法分离效果好、线性范围宽、灵敏度高、方法持久性好，能够快速有效地检测样品中 N-亚硝基二甲胺（NDMA）的含量。
• Methods for predicting drug sensitivity in patients afflicted with hypertension
  申请人：Hakonarson Hakon

  公开号：US20050032096A1

  公开（公告）日：2005-02-10

  Methods are disclosed for predicting the efficacy of a drug for treating hypertension in a patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile from the sample in the absence and presence of in vitro modulation of the cells with specific mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarity between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating hypertension in the patient.

  本发明公开了用于预测治疗患者高血压药物疗效的方法，包括：从患者体内获取细胞样本；在体外用特定介质调节细胞的情况下和存在情况下从样本中获取基因表达谱；以及将样本的基因表达谱与参考基因表达谱进行比较，其中样本表达谱与参考表达谱之间的相似性可预测治疗患者高血压药物的疗效。
• [EN] DETECTION METHOD FOR N-NITROSODIMETHYLAMINE IMPURITIES<br/>[FR] PROCÉDÉ DE DÉTECTION D'IMPURETÉS DE N-NITROSODIMÉTHYLAMINE<br/>[ZH] 一种N-亚硝基二甲胺杂质的检测方法
  申请人：ZHEJIANG HUAHAI PHARM CO LTD

  公开号：WO2020010516A1

  公开（公告）日：2020-01-16

  一种N-亚硝基二甲胺(NDMA)杂质的检测方法，其包括：(1)获得含有待测样品的供试品溶液；(2)采用气质联用法对所述供试品溶液进行检测，以确定样品中N-亚硝基二甲胺杂质的含量。本发明所提供的方法分离效果好，线性范围宽，并且灵敏度高、方法耐用性好，可以快速有效地检测样品中N-亚硝基二甲胺(NDMA)含量。