3,16-bis-(1-methyl-1H-indol-3-yl)-1,5,14,18-tetraoxacyclohexacosane-2,4,15,17-tetraone | 1006060-68-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: 3,16-bis-(1-methyl-1H-indol-3-yl)-1,5,14,18-tetraoxacyclohexacosane-2,4,15,17-tetraone
• 英文别名: 3,16-Bis(1-methylindol-3-yl)-1,5,14,18-tetraoxacyclohexacosane-2,4,15,17-tetrone
• CAS: 1006060-68-9
• 化学式: C₄₀H₅₀N₂O₈
• 分子量: 686.846
• InChiKey: ARNHXWHPSSKXQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  50
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-甲基吲哚 、 3,16-bisdiazo-1,5,14,18-tetraoxacyclohexacosane-2,4,15,17-tetraone 在 dirhodium tetraacetate 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以53%的产率得到3,16-bis-(1-methyl-1H-indol-3-yl)-1,5,14,18-tetraoxacyclohexacosane-2,4,15,17-tetraone
  参考文献：
  名称：

  Reactions of macrocyclic rhodium carbenoids: regioselective synthesis of indol-3-yl macrocyclic lactones and cryptands

  摘要：

  A wide variety of new macrocyclic diazocarbonyl compounds with various spacers was synthesized. Macrocyclic rhodium(H) carberioid insertion with various substituted indoles was performed to afford regioselectively, indol-3-yl macrocyclic di- or tetralactones (C3-alkylation). Double carberioid insertion was also performed to afford indolyl cryptand molecules. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.102

文献信息

• Reactions of macrocyclic rhodium carbenoids: regioselective synthesis of indol-3-yl macrocyclic lactones and cryptands
  作者：Sengodagounder Muthusamy、Boopathy Gnanaprakasam

  DOI：10.1016/j.tetlet.2007.11.102

  日期：2008.1

  A wide variety of new macrocyclic diazocarbonyl compounds with various spacers was synthesized. Macrocyclic rhodium(H) carberioid insertion with various substituted indoles was performed to afford regioselectively, indol-3-yl macrocyclic di- or tetralactones (C3-alkylation). Double carberioid insertion was also performed to afford indolyl cryptand molecules. (C) 2007 Elsevier Ltd. All rights reserved.