5-tert-Butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs
摘要:
Pantothenate synthetase (PS) is one of the potential new antimicrobial targets that may also be useful for the treatment of the nonreplicating persistent forms of Mycobacterium tuberculosis. In this Letter we present a series of 5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent Mycobacterium tuberculosis PS inhibitors, their in silico molecular design, synthesis, and inhibitory activity.
5-<i>tert</i>-Butyl-<i>N</i>-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[<i>d</i>]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors of <i>Mycobacterium tuberculosis</i> Pantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs
作者:Subash Velaparthi、Michael Brunsteiner、Reaz Uddin、Baojie Wan、Scott G. Franzblau、Pavel A. Petukhov
DOI:10.1021/jm701372r
日期:2008.4.1
Pantothenate synthetase (PS) is one of the potential new antimicrobial targets that may also be useful for the treatment of the nonreplicating persistent forms of Mycobacterium tuberculosis. In this Letter we present a series of 5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent Mycobacterium tuberculosis PS inhibitors, their in silico molecular design, synthesis, and inhibitory activity.