2-(4-hydroxy-3-methoxyphenyl)-3-(10-hydroxy-10-oxo-5H-phenophosphazinin-2-yl)-1,3-thiazolidin-4-one | 1146702-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(4-hydroxy-3-methoxyphenyl)-3-(10-hydroxy-10-oxo-5H-phenophosphazinin-2-yl)-1,3-thiazolidin-4-one
• CAS: 1146702-28-4
• 化学式: C₂₂H₁₉N₂O₅PS
• 分子量: 454.443
• InChiKey: WACSYBFINBOPQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  、 巯基乙酸 以 N,N-二甲基甲酰胺 为溶剂， 以83.9%的产率得到2-(4-hydroxy-3-methoxyphenyl)-3-(10-hydroxy-10-oxo-5H-phenophosphazinin-2-yl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Novel Organophosphorus Compounds as Potential Antimicrobial Agents

  摘要：

  The 4-Thiazolidinone derivatives of phenophosphazines were synthesized by a reaction of Schiff base derivative of phenophosphazine with Thyoglycollic acid in molar ratio of 1:3 using DMF as solvent. Possible structures have been proposed based on elemental analysis, IR and H-1 NMR spectral studies. The antibacterial and antifungal activities of these derivatives have been evaluated against pathogens E. coli, S. typhi, S. aureus, B. subtilis, A. niger, and C. Albicans.

  DOI：

  10.1080/10426500701640827