(E)-1-(4-(3-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)phenyl)-N,N,N-trimethylmethanaminium chloride hydrochloride | 1017278-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(4-(3-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)phenyl)-N,N,N-trimethylmethanaminium chloride hydrochloride
• 英文别名: [4-[(E)-3-[5-amino-1-(chloromethyl)-1,2-dihydrobenzo[e]indol-3-yl]-3-oxoprop-1-enyl]phenyl]methyl-trimethylazanium;chloride;hydrochloride
• CAS: 1017278-91-9
• 化学式: C₂₆H₂₉ClN₃O*ClH*Cl
• 分子量: 506.903
• InChiKey: TUQQQPZYWRUHMK-HPAIREQNSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide 在 盐酸 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 16.0h， 以79%的产率得到(E)-1-(4-(3-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)phenyl)-N,N,N-trimethylmethanaminium chloride hydrochloride
  参考文献：
  名称：

  Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure–activity relationships

  摘要：

  Quaternary salt analogues based on the DNA minor groove binder and adenine N3 alkylating agent 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole (aminoCBI) show remarkable effects on the body weight of mice (a long-term failure to gain weight relative to matched controls with no loss of appetite or perceptible deterioration in health) following administration of a single (non-toxic) dose between about 0.5-5 mu mol/kg. The nature of the quaternizing group was not important, but a related hydroxyCBI analogue was much less effective. Compounds where the chloro group was replaced by a hydrogen or hydroxy group (thus abrogating DNA alkylating capability) showed no weight control activity. It is speculated, based on other studies, that the marked long-term weight control effect is due to inhibition of bile flow into the intestine and reduced absorption of triglycerides, together with accelerated cell death in spleen and white adipose tissues due to drug accumulation there. This class of compound may serve as interesting tools for further study of these phenomena. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.12.007

文献信息

• Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure–activity relationships
  作者：Moana Tercel、Ralph J. Stevenson、Guo-Liang Lu、Stephen M. Stribbling、William R. Wilson、Michele A. Tatnell、Rebecca N. Marnane、Kathleen G. Mountjoy、William A. Denny

  DOI：10.1016/j.bmc.2011.12.007

  日期：2012.1

  Quaternary salt analogues based on the DNA minor groove binder and adenine N3 alkylating agent 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole (aminoCBI) show remarkable effects on the body weight of mice (a long-term failure to gain weight relative to matched controls with no loss of appetite or perceptible deterioration in health) following administration of a single (non-toxic) dose between about 0.5-5 mu mol/kg. The nature of the quaternizing group was not important, but a related hydroxyCBI analogue was much less effective. Compounds where the chloro group was replaced by a hydrogen or hydroxy group (thus abrogating DNA alkylating capability) showed no weight control activity. It is speculated, based on other studies, that the marked long-term weight control effect is due to inhibition of bile flow into the intestine and reduced absorption of triglycerides, together with accelerated cell death in spleen and white adipose tissues due to drug accumulation there. This class of compound may serve as interesting tools for further study of these phenomena. (C) 2011 Elsevier Ltd. All rights reserved.