3-(4-methoxyphenyl)benzo[d]thiazol-2(3H)-imine | 1037240-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 3-(4-methoxyphenyl)benzo[d]thiazol-2(3H)-imine
• 英文别名: 3-(4-Methoxyphenyl)-1,3-benzothiazol-2-imine
• CAS: 1037240-65-5
• 化学式: C₁₄H₁₂N₂OS
• 分子量: 256.328
• InChiKey: YBTLIWDHTTZUKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基苯并噻唑 、 4-碘苯甲醚 在 potassium phosphate 、 copper(l) iodide 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以66%的产率得到3-(4-methoxyphenyl)benzo[d]thiazol-2(3H)-imine
  参考文献：
  名称：

  Pyrrole-2-carboxylic Acid as a Ligand for the Cu-Catalyzed Reactions of Primary Anilines with Aryl Halides

  摘要：

  Pyrrole 2-carboxylic acid (L5) was found to be an effective ligand for the Cu-catalyzed monoarylation of anilines with aryl iodides and bromides. Under the reported conditions (10% CuI/20% L5/DMSO/K(3)PO(4)/80-100 degrees C/20-24 h), a variety of useful functional groups were tolerated, and moderate to good yields of the diaryl amine products were obtained.

  DOI：

  10.1021/jo8008676

文献信息

• Pyrrole-2-carboxylic Acid as a Ligand for the Cu-Catalyzed Reactions of Primary Anilines with Aryl Halides
  作者：Ryan A. Altman、Kevin W. Anderson、Stephen L. Buchwald

  DOI：10.1021/jo8008676

  日期：2008.7.1

  Pyrrole 2-carboxylic acid (L5) was found to be an effective ligand for the Cu-catalyzed monoarylation of anilines with aryl iodides and bromides. Under the reported conditions (10% CuI/20% L5/DMSO/K(3)PO(4)/80-100 degrees C/20-24 h), a variety of useful functional groups were tolerated, and moderate to good yields of the diaryl amine products were obtained.