2,3-Dichloro-4-ethylpyridine | 92759-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,3-Dichloro-4-ethylpyridine
• CAS: 92759-36-9
• 化学式: C₇H₇Cl₂N
• 分子量: 176.04
• InChiKey: RXNNIXJVRRLILL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] RADIOLABELLED mGLuR2 PET LIGANDS<br/>[FR] LIGANDS RADIOMARQUÉS POUR LA TOMOGRAPHIE PAR ÉMISSION DE POSITRONS DU MGLUR2
  申请人：JANSSEN PHARMACEUTICALS INC

  公开号：WO2012062752A1

  公开（公告）日：2012-05-18

  The present invention relates to novel, selective, radiolabelled mGluR2 ligands which are useful for imaging and quantifying the metabotropic glutamate receptor mGluR2 in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and to precursors of said compounds.

  本发明涉及一种新颖的、选择性的、放射标记的mGluR2配体，用于利用正电子发射断层扫描（PET）在组织中成像和定量测量代谢型谷氨酸受体mGluR2。该发明还涉及包含这种化合物的组合物，制备这种化合物和组合物的方法，利用这种化合物和组合物在体内或体外成像组织、细胞或宿主，以及这种化合物的前体。
• Continuous process for preparing 5-oxo-2,4-dichloro-4-substituted pentanenitriles
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0119683A1

  公开（公告）日：1984-09-26

  A continuous process for preparing 5-oxo-2,4-dichloro-4-alkyl or aryl pentanenitriles, e.g., 5-oxo-2,4-dichloro-4-methylpentanenitrile-1 by reacting an a,a-dichloroaldehyde with an acrylonitrile in a coil reactor.

  一种在盘管反应器中通过 a,a-二氯醛与丙烯腈反应制备 5-氧代-2,4-二氯-4-烷基或芳基戊腈（例如 5-氧代-2,4-二氯-4-甲基戊腈-1）的连续工艺。
• [DE] CYCLOHEXYLMETHYL- UND CYCLOHEXYLIDENMETHYL-PYRIDINE, VERFAHREN ZU IHRER HERSTELLUNG, DIESE ENTHALTENDE MITTEL UND IHRE VERWENDUNG ALS SCHÄDLINGSBEKÄMPFUNGSMITTEL UND FUNGIZIDE<br/>[EN] CYCLOALKYLMETHYL- AND CYCLOALKYLIDENEMETHYL PYRIDINES, PROCESSES FOR THEIR PRODUCTION, AGENTS CONTAINING THEM AND THEIR USE AS PESTICIDES AND FUNGICIDES<br/>[FR] CYCLOALKYLMETHYL- ET CYCLOALKYLIDENE-METHYL-PYRIDINES, LEURS PROCEDES DE FABRICATION, AGENTS RENFERMANT CES COMPOSES ET LEUR UTILISATION COMME PESTICIDES ET FONGICIDES
  申请人：HOECHST SCHERING AGREVO GMBH

  公开号：WO1997019923A1

  公开（公告）日：1997-06-05

  (DE) Die Erfindung betrifft Verbindungen der Formel (a) sowie deren N-Oxide und Salze, worin Q gegebenenfalls substituiertes 4-Pyridyl bedeutet; R1 und R2 H, Alkyl, Alkenyl, Halogenalkyl, Halogenalkenyl, Aryl oder Aralkyl bedeutet, R3 H bedeutet; oder R1 + R3 gemeinsam eine Bindung sind und R2 wie oben definiert ist; R4 Alkyl, Alkenyl, Alkoxy, Alkanoyloxy, Alkenyloxy, Acyl, Alkoxycarbonyl, Alkenyloxycarbonyl, Halogenalkyl, Halogenalkenyl, Halogenalkoxy, Halogenalkenyloxy, Halogenaryl, Halogenalkoxycarbonyl, Aryl, Aralkyl, Heteroaryl oder Heteroarylalkyl bedeutet; p = 2 bis 7 ist und n = 1, 2 oder 3 ist. Die Erfindung betrifft weiterhin Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide.(EN) The invention concerns compounds of formula (a) and their N-oxides and salts, Q meaning optionally substituted 4-pyridyl; R1 and R2 meaning H, alkyl, alkenyl, alkyl halide, alkenyl halide, aryl or aralkyl; R3 meaning H; or R1 + R3 together being a bond and R2 being defined as above; R4 being alkyl, alkenyl, alkoxy, alkanoyloxy, alkenyloxy, acyl, alkoxycarbonyl, alkenyloxycarbonyl, alkyl halide, alkenyl halide, alkoxy halide, alkenyloxy halide, acyl halide, alkoxycarbonyl halide, aryl, aralkyl, heteroaryl or heteroarylalkyl; p being 2 to 7; and n being 1, 2 or 3. The invention further concerns processes for the production of these compounds and their use as pesticides and fungicides.(FR) L'invention concerne des composés de formule (a), ainsi que leurs N-oxydes et leurs sels, formule dans laquelle Q désigne un 4-pyridyle éventuellement substitué; R1 et R2 désignent un H, alkyle, alkényle, halogénure d'alkyle, halogénure d'alkényle, aryle ou aralkyle, R3 est un H, ou bien R1 + R3 représentent, ensemble, une liaison, et R2 est tel que défini précédemment; R4 est un alkyle, alkényle, alkoxy, alkanoyloxy, alkényloxy, acyle, alkoxycarbonyle, alkényloxycarbonyle, halogénure d'alkyle, halogénure d'alkényle, halogénure d'alkoxy, halogénure d'alkényloxy, halogénure d'acyle, halogénure d'alkoxycarbonyle, aryle, aralkyle, hétéroaryle ou hétéroarylalkyle; p = 2 à 7 et n = 1, 2 ou 3. L'invention concerne en outre des procédés de fabrication de ces composés, des agents les renfermant, ainsi que leur utilisation comme pesticides et fongicides.

  该发明涉及化合物（如式（a）所示）、它们的N-氧化物和盐，其中Q可能代表取代的4-吡啶。R1和R2代表氢、烷基、烯基、含卤烷基、含卤烯基、 aromatique或 aralkyl；R3代表氢；或R1 + R3构成键，R2依照上述定义；R4代表烷基、烯基、甲氧基、甲基甲氧基、烯基甲氧基、acyl、 fonts）、甲基氧羰基、烯基氧羰基、卤烷基、卤烯基、卤甲氧基、卤烯氧基、卤acyl、 haloxycarbonyl、aromatic、aralkyl、heteroaromatic或heteroarylalkyl；p = 2至7，且n = 1, 2或3。该发明同样涉及上述化合物的制备方法、包含该化合物的试剂及其用作生物除虫剂和 fungicides的应用。
• CHEMOKINE CXCR4 AND CCR5 RECEPTOR MODULATORS AND USED RELATED THERETO
  申请人：Emory University

  公开号：EP3143005B1

  公开（公告）日：2021-07-07
• Chemokine CXCR4 and CCR5 Receptor Modulators and Uses Related Thereto
  申请人：Emory University

  公开号：US20170137401A1

  公开（公告）日：2017-05-18

  The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of viral infections such as HIV or for managing cancer.