5-Fluoro-2-propoxybenzoic acid | 127980-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Fluoro-2-propoxybenzoic acid
• CAS: 127980-13-6
• 化学式: C₁₀H₁₁FO₃
• 分子量: 198.19
• InChiKey: KRKMAJFXGVTCMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1<br/>[FR] COMPOSÉS UTILES EN TANT QU'INHIBITEURS D'ALCAT 1
  申请人：PERENNA PHARMACEUTICALS INC

  公开号：WO2018178304A1

  公开（公告）日：2018-10-04

  Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.

  ALCAT1的抑制剂具有一般公式：(I)。这些化合物提供了治疗衰老和与年龄相关疾病的方法。
• Purine compounds, process for their preparation and pharmaceutical compositions
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0352960A2

  公开（公告）日：1990-01-31

  Compounds of the formula (1): and pharmaceutically acceptable salts thereof, wherein R¹ is C???alkyl, C???alkenyl, C???cycloalkylC???alkyl, phenylC???alkyl or C???alkyl substituted by 1 to 6 fluoro groups; R² is hydrogen, hydroxy, C???alkyl, phenyl, mercapto, C???alkylthio, CF? or amino; R³ is hydrogen, nitro, amino, C???alkanoylamino, C???­alkoxy, C???alkyl, halo, SO?NR?R?, CONR?R?, cyano or C???alkylS(O)n; R? and R? are independently hydrogen or C???alkyl; and n is 0, 1 or 2; provided that R³ is not hydrogen when R¹ is C???alkyl or C???alkenyl and R² is hydrogen or hydroxy. Processes for their preparation, pharmaceutical compositions comprising them and their use as medicaments are described.

  式（1）的化合物： 及其药学上可接受的盐，其中 R¹ 是 C???烷基、C???烯基、C???环烷基 C???烷基、苯基 C???烷基或被 1 至 6 个氟基团取代的 C??烷基； R² 是氢、羟基、C??烷基、苯基、巯基、C??烷硫基、CF?或氨基； R³ 是氢、硝基、氨基、C???烷酰氨基、C???烷氧基、C??烷基、卤素、SO?NR?R?、CONR?R?、氰基或 C??烷基S(O)n； R? 和 R? 独立地为氢或 C??烷基；以及 n 是 0、1 或 2； 当 R¹ 为 C???烷基或 C???烯基，且 R² 为氢或羟基时，R³ 不是氢。本文介绍了它们的制备方法、包含它们的药物组合物以及它们作为药物的用途。
• Compounds useful as inhibitors of ALCAT 1
  申请人：PERENNA PHARMACEUTICALS, INC.

  公开号：US11208404B2

  公开（公告）日：2021-12-28

  Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.

  ALCAT1 的抑制剂通式如下：(I).这些化合物可治疗衰老和与衰老有关的疾病。
• EP0352960B1
  申请人：——

  公开号：EP0352960B1

  公开（公告）日：1994-10-26
• COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1
  申请人：Perenna Pharmaceuticals, Inc.

  公开号：EP3601274A1

  公开（公告）日：2020-02-05