2-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-N-[2-(pyrazin-2-ylamino)ethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-N-[2-(pyrazin-2-ylamino)ethyl]benzamide
• 化学式: C₁₈H₁₉N₅OS₂
• 分子量: 385.5
• InChiKey: NSIMOUFWSBPFQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] THERAPEUTIC COMPOUNDS<br/>[FR] COMPOSÉS THÉRAPEUTIQUES
  申请人：UNIV RUTGERS

  公开号：WO2017222930A1

  公开（公告）日：2017-12-28

  Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.

  公开了公式I的某些化合物：I及其盐，包括其药学上可接受的盐。还公开了包括公式I化合物的药物组合物，制备公式I化合物的过程，用于制备公式I化合物的中间体以及使用公式I化合物的治疗方法。
• Aryl and heteroaryl amides for use as anti-proliferative, anti-thrombotic, and anti-viral agents
  申请人：Rutgers, The State University of New Jersey

  公开号：US10851096B2

  公开（公告）日：2020-12-01

  Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.

  本研究公开了某些式 I：I 及其盐类，包括其药学上可接受的盐类。还公开了包含式 I 化合物的药物组合物、制备式 I 化合物的工艺、用于制备式 I 化合物的中间体以及使用式 I 化合物的治疗方法。
• THERAPEUTIC COMPOUNDS
  申请人：Rutgers, the State University of New Jersey

  公开号：EP3471729A1

  公开（公告）日：2019-04-24
• Therapeutic Compounds
  申请人：WELSH William J.

  公开号：US20190127361A1

  公开（公告）日：2019-05-02

  Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.