N''-(2-Aminophenyl)guanidine | 113630-29-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N''-(2-Aminophenyl)guanidine
• 英文别名: 2-(2-aminophenyl)guanidine
• CAS: 113630-29-8
• 化学式: C₇H₁₀N₄
• mdl: MFCD12024866
• 分子量: 150.18
• InChiKey: PNTBLQOLHRQIRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Methods and Intermediates for the Preparation of Optionally Radio-Labeled Imatinib
  申请人：Salter Rhys

  公开号：US20120316338A1

  公开（公告）日：2012-12-13

  The invention relates to new processes for the manufacture of N-5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine (compound of formula I, new processes for the manufacture of metabolites of N-5[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine observed after administration of the compound to warm-blooded animals as well as to intermediates used in said processes. New starting materials as well as processes for the preparation thereof are likewise the subject of this invention. The processes described herein are especially suitable to furnish said compounds having isotopic labeling. The such obtained labeled compounds are in particular suitable to track and to investigate into the metabolism of N-5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and its pharmaceutically acceptable salts in clinical and pre-clinical studies.

  本发明涉及制备N-5-[4-(4-甲基哌嗪甲基)-苯甲酰氨基]-2-甲基苯基}-4-(3-吡啶基)-2-嘧啶胺（化合物I的公式），制备该化合物在温血动物中给药后代谢产物的新工艺，以及用于该工艺的中间体。本发明还涉及新的起始材料及其制备工艺。本文所述的工艺特别适用于提供具有同位素标记的上述化合物。因此获得的标记化合物特别适用于跟踪并研究N-5-[4-(4-甲基哌嗪甲基)-苯甲酰氨基]-2-甲基苯基}-4-(3-吡啶基)-2-嘧啶胺及其药学上可接受的盐在临床和临床前研究中的代谢。
• CURABLE COMPOSITION
  申请人：Kaneka Corporation

  公开号：EP1990371A1

  公开（公告）日：2008-11-12

  The present invention has its object to provide a curable composition which comprises a reactive silyl group-containing organic polymer, does not contain, as a silanol condensation catalyst, any organotin type curing catalyst currently of concern because of the toxic feature thereof, is excellent in surface curability and depth curability and, further, can provide cured products excellent in adhesiveness; the above obj ect can be achieved by a curable composition which comprises: an organic polymer (A) containing a silicon-containing group capable of crosslinking under siloxane bond formation; and a guanidine compound (B-1), as a silanol condensation catalyst (B), represented by the general formula (1):         R1N=C(NR12)2     (1) (wherein one of the five R1s is an aryl group and the other four R1s each independently is a hydrogen atom or a hydrocarbon group in which the carbon atom at position 1 is saturated).

  本发明的目的是提供一种可固化组合物，该组合物包括含活性硅烷基团的有机聚合物，作为硅烷醇缩合催化剂，不含任何目前因其毒性特征而受到关注的有机锡类固化催化剂，具有优异的表面固化性和深度固化性，而且，可提供具有优异粘合性的固化产品；上述目的可通过一种可固化组合物来实现，该组合物包括：含硅烷基团的有机聚合物(A)；作为硅烷醇缩合催化剂(B)的胍化合物(B-1)：一种有机聚合物 (A)，其中含有能在硅氧烷键形成下交联的含硅基团；和一种胍化合物 (B-1)，作为硅醇缩合催化剂 (B)，由通式 (1) 表示： R1N=C(NR12)2 (1) (其中五个 R1s 中的一个为芳基，另外四个 R1s 分别独立地为氢原子或碳原子位于第 1 位为饱和的烃基）。
• METHODS AND INTERMEDIATES FOR THE PREPARATION OF OPTIONALLY RADIO-LABELED IMATINIB
  申请人：Novartis AG

  公开号：EP1896447A2

  公开（公告）日：2008-03-12
• JPH01304881A
  申请人：——

  公开号：JPH01304881A

  公开（公告）日：1989-12-08
• JPH08176015A
  申请人：——

  公开号：JPH08176015A

  公开（公告）日：1996-07-09