2,4,6,8- tetraphenyl-2,4,6,8-tetraazabicyclo[3.3.0]octane | 188439-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2,4,6,8- tetraphenyl-2,4,6,8-tetraazabicyclo[3.3.0]octane
• 英文别名: 2,4,6,8-Tetraphenyl-2,4,6,8-tetraazabicyclo[3.3.0]octane；1,3,4,6-tetraphenyl-2,3a,5,6a-tetrahydroimidazo[4,5-d]imidazole
• CAS: 188439-79-4
• 化学式: C₂₈H₂₆N₄
• 分子量: 418.541
• InChiKey: VFMGIFVQVTXVFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  13
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4,6,8- tetraphenyl-2,4,6,8-tetraazabicyclo[3.3.0]octane 在 碘 作用下， 以 氯仿 为溶剂， 生成 1,3,4,6-Tetraphenyl-octahydro-imidazo[4,5-d]imidazole; compound with iodine
  参考文献：
  名称：

  Rouhollahi; Kakanejadifard; Farnia, Polish Journal of Chemistry, 1997, vol. 71, # 6, p. 731 - 738

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3,4,6-Tetraphenyl-octahydro-imidazo[4,5-d]imidazole; compound with iodine 以 氯仿 为溶剂， 生成 2,4,6,8- tetraphenyl-2,4,6,8-tetraazabicyclo[3.3.0]octane
  参考文献：
  名称：

  Rouhollahi; Kakanejadifard; Farnia, Polish Journal of Chemistry, 1997, vol. 71, # 6, p. 731 - 738

  摘要：

  DOI：

文献信息

• Synthesis and X-ray structural determination of new aniline derivatives of 2,4,6,8-tetraazabicyclo[3.3.0]octanes; anomeric effect in N-C-N moiety and implications of solvent polarity on 1H-NMR patterns
  作者：Ali Kakanejadifard、S.Morteza F. Farnia

  DOI：10.1016/s0040-4020(96)01143-x

  日期：1997.2

  8-tetraphenyl-2,4,6,8-tetraazabicyclo[3.3.0]octane (1f) with formic acid as catalyst. Nine substituted derivatives of 1f have been prepared in high yield by this synthetic method. X-ray analysis revealed the existence of an anomeric effect, in N-C-N moieties manifested by reduction in N-pyramidality and short CN bond lengths. Moreover, 1H-NMR studies showed the dependency of methylenic protons splitting pattern

  以化学计量比将苯胺与乙二醛和甲醛缩合，生成2,4,6,8-四苯基-2,4,6,8-四氮杂双环[3.3.0]辛烷（1f），甲酸为催化剂。通过该合成方法已经高产率地制备了9个1f的取代衍生物。X射线分析揭示了NCN部分中存在异头作用，表现为N-金字塔性降低和CN键长度短。此外，1 H-NMR研究表明亚甲基质子分裂模式对溶剂极性的依赖性。
• Method for the preparation of optical (bio)chemical sensor devices
  申请人：——

  公开号：US20020115224A1

  公开（公告）日：2002-08-22

  The present invention relates to a method for the preparation of a miniaturized optical chemical or biochemical sensor device (e.g. bulk optode, etc. for ion sensing), said device comprising a substrate material having a planar surface portion, said planar surface representing a transducer based on an optical phenomenon such as surface plasmon resonance based on evanescent waves, reflection or transmission; said planar surface portion having arranged thereon an multi-analyte array of (bio)chemical sensor dots located at spatially separated predetermined positions of the planar surface, said sensor dots including (i) a polymer matrix, and (ii) one or more (bio)chemical recognition moieties, the method comprising (a) providing a substrate material having a planar surface portion; (b) providing one or more spotting fluid(s); (c) depositing the one or more spotting fluid(s) onto the planar surface portion of the substrate material by means of a pin-printer deposition mechanism (arrayer) and allowing the spotting fluid(s) to consolidate.

  本发明涉及一种制备微型光学化学或生化传感器装置（如用于离子传感的散装光电极等）的方法。本发明涉及一种用于制备微型化光学化学或生化传感器装置（如用于离子传感的体式光电二极管等）的方法，所述装置包括具有平面表面部分的基底材料，所述平面表面代表基于光学现象（如基于蒸发波、反射或透射的表面等离子体共振）的换能器；所述平面表面部分上排列有位于平面表面空间上分离的预定位置的（生物）化学传感点的多分析阵列，所述传感点包括 (i) 聚合物基质，和 (ii) 一个或多个（生物）化学识别分子，该方法包括 (a) 提供具有平面表面部分的基底材料；(b) 提供一种或多种点阵液； (c) 通过针刺机沉积机构（阵列器）将一种或多种点阵液沉积到基底材料的平面部分上，并使点阵液固化。
• METHOD FOR THE PREPARATION OF OPTICAL (BIO)CHEMICAL SENSOR DEVICES
  申请人：Vir A/S

  公开号：EP1360007A1

  公开（公告）日：2003-11-12
• [EN] METHOD FOR THE PREPARATION OF OPTICAL (BIO)CHEMICAL SENSOR DEVICES<br/>[FR] PROCEDE DE PREPARATION DE DISPOSITIFS DE DETECTION OPTIQUE (BIO)CHIMIQUES
  申请人：VIR AS

  公开号：WO2002066162A1

  公开（公告）日：2002-08-29

  The present invention relates to a method for the preparation of a miniaturized optical chemical or biochemical sensor device (e.g. bulk optode, etc. for ion sensing), said device comprising a substrate material having a planar surface portion, said planar surface representing a transducer based on an optical phenomenon such as surface plasmon resonance based on evanescent waves, reflection or transmission; said planar surface portions having arranged thereon an multi-analyte array of (bio)chemical sensor dots located at spatially separated predetermined positions of the planar surface, said sensor dots including (i) a polymer matrix, and (ii) on or more (bio)chemical recognition moieties, the method comprising (a) providing a substrate material having a planar surface portion; (b) providing one or more spotting fluid(s); (c) depositing the one or more spotting fluid(s) onto the planar surface portion of the substrate material by means of a pin-printer depositing mechanism (arrayer) and allowing the spotting fluid(s) to consolidate.