4-Hydroperoxyphenol | 117711-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Hydroperoxyphenol
• CAS: 117711-54-3
• 化学式: C₆H₆O₃
• 分子量: 126.11
• InChiKey: KCIZUAMTTBFYNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE<br/>[FR] PIPÉRIDINE-2,6-DIONES UTILISÉES COMME AGENTS DE DÉGRADATION À PETITES MOLÉCULES D'HÉLIOS ET MÉTHODES D'UTILISATION
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2021236885A1

  公开（公告）日：2021-11-25

  Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, and tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.

  本文披露了一些化合物及其药用盐、水合物、溶剂合物、前药、立体异构体和互变异构体，这些化合物可能导致各种蛋白质的降解，例如IKZF2（Helios）。同时还披露了含有这些化合物的药物组合物，以及使用这些化合物治疗与Helios相关的疾病和障碍，并可能从Helios降解中受益的方法。
• [EN] SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE<br/>[FR] AGENTS DE DÉGRADATION À PETITES MOLÉCULES D'HÉLIOS ET PROCÉDÉS D'UTILISATION
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2021087093A1

  公开（公告）日：2021-05-06

  Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.

  本文披露了一些化合物及其药用可接受的盐、水合物、溶剂合物、前药、立体异构体或互变异构体，这些化合物可能导致各种蛋白质（例如IKZF2（Helios））的降解。还披露了含有该化合物的药物组合物，以及制备和使用这些化合物治疗与Helios相关的疾病和障碍的方法，这些疾病和障碍可能受益于Helios的降解。
• Rust disease control by Aphanocladium album and/or Beauveria brongniartii
  申请人：Subbiah Ven

  公开号：US20070110726A1

  公开（公告）日：2007-05-17

  There is disclosed a method and composition for controlling rust disease in plants. Metabolites produced by Aphanocladium album mycoparasites are recovered and applied in an effective amount to plants at risk for acquiring rust disease More specifically, the application of the metabolite converts infective urediniospores that cause rust disease into non-infective teliospores. In a more specific aspect, the metabolite is reacted with another substance or under a specific reaction to result in a different compound which is also effective against rust disease.

  本发明揭示了一种用于控制植物锈病的方法和组合物。通过Aphanocladium album真菌寄生体产生的代谢物被提取并以有效量施用于有患锈病风险的植物上。更具体地，代谢物的施用将导致引起锈病的传染性锈子孢子转变为非传染性的子囊孢子。在更具体的方面，这种代谢物与另一种物质或在特定反应条件下反应，形成对锈病也有效的不同化合物。
• STRUCTURE OF ADJUSTABLE STERIC HINDRANCE WEAK BASIC LIGHT STABILIZER AND PREPARATION METHOD AND APPLICATION THEREOF
  申请人：Shaoxing Ruikang Biotechnologies Co., Inc

  公开号：US20220145045A1

  公开（公告）日：2022-05-12

  The field of new compounds and synthesis methods thereof are related, and particularly to a structure of a steric hindrance adjustable weak base light stabilizer and a preparation method and application thereof. According to the innovative light stabilizer, a steric hindrance thereof is adjusted by establishing substituent generating the steric hindrance around nitrogen atoms; moreover, an electronegativity of the nitrogen atom can be influenced by adjusting a distance of a polar group, so that an alkalinity or a nucleophilicity of the nitrogen atom is adjusted. A desired effect is obtained by adjusting a steric hindrance and a nucleophilic property or an alkalinity where the nitrogen atom is located, so that an application range of the innovative light stabilizer is widened, and the innovative light stabilizer is suitable for PC, polyester, PVC and other slightly acidic or certain electrophilic polymer materials to serve as a light stability protecting aid.

  新化合物和合成方法领域相关，特别是一种结构可调节立体位阻的弱碱光稳定剂及其制备方法和应用。根据这种创新的光稳定剂，通过在氮原子周围引入产生立体位阻的取代基来调节其立体位阻；此外，通过调节极性基团的距离可以影响氮原子的电负性，从而调节氮原子的碱性或亲核性。通过调节氮原子所在位置的立体位阻、亲核性或碱性，可以获得所需的效果，从而扩大创新光稳定剂的应用范围，使其适用于PC、聚酯、PVC等微酸性或某些亲电性聚合材料，作为光稳定保护助剂。
• [EN] PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE<br/>[FR] AGENTS DE DÉGRADATION DE PROTÉINE HELIOS À BASE DE PETITES MOLÉCULES DE PIPÉRIDINYL ET PROCÉDÉS D'UTILISATION
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2022081976A1

  公开（公告）日：2022-04-21

  Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.

  本发明涉及化合物及其制药可接受的盐、水合物、溶剂合物、前药、立体异构体或互变异构体，其可导致各种蛋白质如IKZF2（Helios）的降解。本发明还涉及含有该化合物的制药组合物，以及使用该化合物治疗与Helios相关的疾病和障碍的方法，这些疾病和障碍可能受益于Helios的降解。