3,5-diamino-6-(4-amino-2,3-dichlorophenyl)-1,2,4-triazine | 139400-95-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-diamino-6-(4-amino-2,3-dichlorophenyl)-1,2,4-triazine
• 英文别名: 6-(4-Amino-2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
• CAS: 139400-95-6
• 化学式: C₉H₈Cl₂N₆
• 分子量: 271.109
• InChiKey: AHGKYVYNINQFMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Pharmacologically active CNS compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0459829A1

  公开（公告）日：1991-12-04

  The invention provides compounds of formula (I) wherein at least one of Rl, R2 and R3 is chloro and the others are selected from hydrogen and chloro; and R4 and R5 are the same or different and are each alkyl or hydrogen. The compounds may be used for the treatment or prophylaxis of a neurodegenerative of other neurological disorder of the CNS, the aetiology of which includes excessive release of the neurotransmitter glutamate.

  本发明提供了式（I）的化合物，其中至少有R1、R2和R3中的一个是氯，其余的选择自氢和氯；而R4和R5相同或不同，且分别是烷基或氢。这些化合物可用于治疗或预防中枢神经系统的神经退行性或其他神经系统疾病，其病因包括神经递质谷氨酸过度释放。
• Novel therapeutic agents for membrane transporters
  申请人：——

  公开号：US20030044845A1

  公开（公告）日：2003-03-06

  Novel multi-binding compounds (agents) are disclosed which bind cell membrane transporters including ion channels, molecular transporters and ion pumps. The compounds of this invention comprise from 2 to 10 ligands each of which can bind to such cellular transporters to modulate the biological processes/functions thereof. Each of the ligands is covalently attached to a linker (framework) to provide for a multi-binding compound. The linker is selected such that the multi-binding compound exhibits increased modulation of the biological processes/functions of the transporter as compared to the aggregate of the individual ligand units made available for binding to the transporter.

  本发明揭示了一种新型多重结合化合物（试剂），其结合细胞膜转运体，包括离子通道、分子转运体和离子泵。本发明的化合物包括2到10个配体，每个配体都可以结合到这些细胞转运体上，以调节其生物过程/功能。每个配体都共价地连接到一个连接器（框架）上，以提供多重结合化合物。所选择的连接器是为了使多重结合化合物相比可用于结合转运体的单个配体单元的聚合体表现出增强的调节转运体的生物过程/功能的特性。
• EP1089749A4
  申请人：——

  公开号：EP1089749A4

  公开（公告）日：2001-04-11
• NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS
  申请人：Advanced Medicine, Inc.

  公开号：EP1089749A1

  公开（公告）日：2001-04-11
• [EN] NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS<br/>[FR] AGENTS THERAPEUTIQUES AGISSANT SUR LES TRANSPORTEURS MEMBRANAIRES
  申请人：——

  公开号：WO1999064045A9

  公开（公告）日：2001-07-05

  [EN] Disclosed are multibinding compounds that bind cell membrane transporters and modulate their activity. The multibinding compounds contain from 2 to 10 ligands covalently attached to one or more linkers.
  [FR] Cette invention concerne des composés à liaisons multiples et en module l'activité. Ces composés comportent de 2 à 10 ligands liés à un ou plusieurs lieurs.