3-Carboxymethyl-2-oxo-hexahydroazepin | 827-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3-Carboxymethyl-2-oxo-hexahydroazepin
• 英文别名: (2-oxo-azepan-3-yl)-acetic acid；2-(2-Oxoazepan-3-yl)acetic acid
• CAS: 827-67-8
• 化学式: C₈H₁₃NO₃
• mdl: MFCD20647351
• 分子量: 171.196
• InChiKey: KDKKRNOYSMNNJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Gastrin releasing peptide compounds
  申请人：Cappelletti Enrico

  公开号：US20060018830A1

  公开（公告）日：2006-01-26

  New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.

  新的改进化合物用于诊断影像或治疗，其化学式为M-N—O—P-G，其中M是具有以下结构的金属螯合剂： 其中R1-R5和FG的定义如本文所述（以金属放射性核素或未配合的形式），N—O—P是含有至少一个非α氨基酸的连接剂，其中该氨基酸具有一个环形基团，至少一个取代的胆汁酸或至少一个非α氨基酸，而G是GRP受体靶向肽。在首选实施例中，M是Aazta金属螯合剂或其衍生物。还提供了使用该发明的化合物对患者进行成像和/或提供放射治疗或光疗的方法。还提供了制备诊断成像剂的方法和试剂盒。还提供了制备放射治疗剂的方法和试剂盒。
• Gastrin Releasing Peptide Compounds
  申请人：Cappelletti Enrico

  公开号：US20070231257A1

  公开（公告）日：2007-10-04

  New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.

  新的并且改良的化合物，用于放射性诊断成像或放射治疗，其化学式为M-N-O-P-G，其中M为金属螯合剂（以金属放射性核素形式复合或未复合），N-O-P为连接剂，G为GRP受体靶向肽。本发明还提供了使用该化合物对患者进行成像和/或放射治疗的方法。此外，还提供了一种从该化合物制备诊断成像试剂的方法。还提供了一种制备放射性治疗试剂的方法。
• GASTRIN RELEASING PEPTIDE COMPOUNDS
  申请人：Cappelletti Enrico

  公开号：US20110052491A1

  公开（公告）日：2011-03-03

  New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.

  本发明涉及用于诊断成像或治疗的新型化合物，其化学式为M—N—O—P—G，其中M是光学标记或金属螯合剂（以与金属放射性核素形成络合物或非络合形式存在），N—O—P是连接剂，G是GRP受体靶向肽。本发明还提供了使用该化合物进行患者成像和/或提供放射治疗或光疗的方法。本发明还提供了制备诊断成像剂的方法和试剂盒。本发明还提供了制备放射治疗剂的方法和试剂盒。
• US7226577B2
  申请人：——

  公开号：US7226577B2

  公开（公告）日：2007-06-05
• US7922998B2
  申请人：——

  公开号：US7922998B2

  公开（公告）日：2011-04-12