3-Hydroxy-5-(phenylsulfanyl)pentanoic acid | 254995-16-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-Hydroxy-5-(phenylsulfanyl)pentanoic acid
• 英文别名: 3-hydroxy-5-phenylsulfanylpentanoic acid
• CAS: 254995-16-9
• 化学式: C₁₁H₁₄O₃S
• 分子量: 226.29
• InChiKey: LMBJAVFTESEKLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Particulate construct comprising polyhydroxyalkanoate and method for producing it
  申请人：——

  公开号：US20030194443A1

  公开（公告）日：2003-10-16

  The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.

  本发明提供了一种微粒构造物，例如包含药物的微胶囊，用作缓释制剂，不会出现实际上不可接受的初始爆发释放，但在一定时间内显示实际上可接受的零级释放，并提供了这种微粒构造物的制备方法，以及能够稳定地将药物纳入微粒构造物中，例如微胶囊的高药物含量的缓释制剂，以及这种制备方法。本发明还提供了一种利用高功能聚合物化合物并将油相和/或水相纳入固相的微粒构造物，以及其制备方法。此外，本发明还提供了一种具有单一聚合物膜的空心结构的微粒构造物，能够在细小的颗粒中包含许多气泡，并提供了一种能够高度重复制备这种构造物的制备方法。根据本发明，可使用具有特定结构的聚羟基烷酸酯和药物制备微粒构造物，该构造物中包含油相和/或水相或气态相。
• Polyhydroxyalkanoate and method of producing same, and w-(2-thienylsulfanyl) alkanoic acid and method of producing same
  申请人：——

  公开号：US20020164726A1

  公开（公告）日：2002-11-07

  PHA containing a novel 3-hydroxy-thioalkanoic acid unit having a highly reactive thienyl group in a side chain thereof, and a method of producing the same are provided. Specifically, 5-(2-thienylsulfanyl) valeric acid represented by Chemical Formula [4] below and 6-(2-thienylsulfanyl) hexanoic acid represented by Chemical Formula [5] below are provided. Further, a method of producing PHA, comprising the step of collecting PHA from cells of a microorganism cultured in a medium containing the valeric acid or hexanoic acid, and a novel PHA represented by Chemical Formula [1] below are provided. 1 (n denotes an integer of 1 to 9)

  本发明提供了一种含有高度反应性噻吩基侧链的新型3-羟基硫代脂肪酸单元的PHA，以及其制备方法。具体地，提供了化学式[4]所表示的5-(2-噻吩基硫代基)戊酸和化学式[5]所表示的6-(2-噻吩基硫代基)己酸。此外，还提供了一种从在含有戊酸或己酸的培养基中培养的微生物细胞中收集PHA的方法，以及化学式[1]所表示的新型PHA。(其中n是1到9的整数)
• Polyhydroxyalkanoate and manufacturing method thereof
  申请人：——

  公开号：US20020160467A1

  公开（公告）日：2002-10-31

  To provide a novel polyhydroxyalkanoate and a mnaufacturing method by a microorganism capable of substantially reducing unintended inonomer units and obtaining the polyhydroxaykanoate in a high yield. A microorganism capable of synthesizing a novel polyhydroxyalkanoate having 3-hydroxy-substituted benzoylalkanoic acid as a monomer unit using a substituted benzoylalkanoic acid as a material is cultured in tha medium containing a substituted benzoylalkanoic acid, then the polyhydroxyalkanoate produced in the cultured bacteria is extracted and recovered.

  提供一种新型聚羟基脂肪酸酯及其制造方法，通过使用一种微生物，能够显著减少不必要的异构体单元，并以高产率获得聚羟基脂肪酸酯。将一种能够使用取代苯甲酰基脂肪酸作为原料，合成具有3-羟基取代苯甲酰基脂肪酸单体的新型聚羟基脂肪酸酯的微生物培养在含有取代苯甲酰基脂肪酸的培养基中，然后提取和回收培养细菌中产生的聚羟基脂肪酸酯。
• Polyhydroxyalkonoate and method of producing same, and w-(2-thienylsulfanyl) alkanoic acid and method of producing same
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20040062811A1

  公开（公告）日：2004-04-01

  PHA containing a novel 3-hydroxy-thioalkanoic acid unit having a highly reactive thienyl group in a side chain thereof, and a method of producing the same are provided. Specifically, 5-(2-thienylsulfanyl) valeric acid represented by Chemical Formula [4] below and 6-(2-thienylsulfanyl) hexanoic acid represented by Chemical Formula [5] below are provided. Further, a method of producing PHA, comprising the step of collecting PHA from cells of a microorganism cultured in a medium containing the valeric acid or hexanoic acid, and a novel PHA represented by Chemical Formula [1] below are provided. 1 (n denotes an integer of 1 to 9)

  本发明提供了含有具有高度反应性噻吩基侧链的新型3-羟基硫代烷酸单元的PHA，以及其制备方法。具体而言，提供了化学式[4]所代表的5-(2-噻吩基硫基)戊酸和化学式[5]所代表的6-(2-噻吩基硫基)己酸。此外，还提供了一种从在含有戊酸或己酸的培养基中培养的微生物细胞中收集PHA的方法，以及化学式[1]所代表的新型PHA。(其中n为1到9的整数)
• Polyhydroxyalkanoate-containing magnetic structure, and manufacturing method and use thereof
  申请人：Yano Tetsuya

  公开号：US20060263432A1

  公开（公告）日：2006-11-23

  A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part and the internal phase part containing a magnetic substance. Accordingly, provided is a microcapsule, which can be suitably used for formation of an active ingredient of a sustained release pharmaceutical preparation or an ultrasonic contrast agent.

  一种含有聚羟基脂肪酸酯和磁性物质的结构，包括一个包含聚羟基脂肪酸酯的外相部分和一个包含在外相部分中的内相部分，其中至少一个外相部分和内相部分含有磁性物质。因此，提供了一种微胶囊，可适用于制备持续释放药物制剂或超声造影剂的活性成分。