1-methyl-2-phenyl-1,2-dihydro-pyridine | 36939-25-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methyl-2-phenyl-1,2-dihydro-pyridine
• 英文别名: 1-Methyl-2-phenyl-1,2-dihydro-pyridin；1-methyl-2-phenylpyridine；1-methyl-2-phenyl-2H-pyridine
• CAS: 36939-25-0
• 化学式: C₁₂H₁₃N
• 分子量: 171.242
• InChiKey: RYSLXXSRXDKEEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-甲基吡啶碘化物 在 四氢呋喃 、 苯基锂 作用下， 生成 1-methyl-2-phenyl-1,2-dihydro-pyridine
  参考文献：
  名称：

  Grashey; Huisgen, Chemische Berichte, 1959, vol. 92, p. 2641,2645

  摘要：

  DOI：

文献信息

• Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp
  申请人：GUILFORD PHARMACEUTICALS, INC.

  公开号：US20010020013A1

  公开（公告）日：2001-09-06

  This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula; 1 A is O or S; R is C 1 -C 10 straight or branched chain alkyl, C 2 -C 10 straight or branched chain alkenyl, C 2 -C 10 straight or branched chain alkynyl, aryl, heteroaryl, carbocycle, or heterocycle; D is a bond, or a C 1 -C 3 straight or branched chain alkyl, C 2 -C 3 straight or branched chain alkenyl, C 2 -C 3 straight or branched chain alkynyl, wherein any of the carbon atoms of said alkyl, alkenyl, or alkynyl of D are optionally replaced with oxygen, nitrogen, or sulfur; and X is aryl, heteroaryl, carbocycle, or heterocycle.

  本发明涉及式 1 的化合物、药物组合物和使用方法； 1 A 是 O 或 S R 是 C 1 -C 10 直链或支链烷基，C 2 -C 10 直链或支链烯基，C 2 -C 10 直链或支链炔基、芳基、杂芳基、碳环或杂环； D 是键，或 C 1 -C 3 直链或支链烷基、C 2 -C 3 直链或支链烯基，C 2 -C 3 直链或支链炔基，其中 D 所述烷基、烯基或炔基的任一碳原子可选地被氧、氮或硫取代；以及 X 是芳基、杂芳基、碳环或杂环。
• ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
  申请人：Rohm And Haas Electronic Materials Korea Ltd.

  公开号：EP3440155B1

  公开（公告）日：2021-02-24
• PHOTODYNAMIC THERAPEUTIC COMPOUNDS AND PHOTODYNAMIC METHODS OF TREATMENT
  申请人：Salt and Light Pharmaceuticals Pty. Ltd.

  公开号：EP3548494A1

  公开（公告）日：2019-10-09
• US6232326B1
  申请人：——

  公开号：US6232326B1

  公开（公告）日：2001-05-15
• [EN] PHOTODYNAMIC THERAPEUTIC COMPOUNDS AND PHOTODYNAMIC METHODS OF TREATMENT<br/>[FR] COMPOSÉS THÉRAPEUTIQUES PHOTODYNAMIQUES ET PROCÉDÉS DE TRAITEMENT PHOTODYNAMIQUE
  申请人：SALT AND LIGHT PHARMACEUTICALS PTY LTD

  公开号：WO2018102849A1

  公开（公告）日：2018-06-14

  The invention provides photodynamic therapeutic compounds and photodynamic methods of treatment. The photodynamic therapeutic compounds may be activated by long wavelength light. The photo-activation by long wavelength light may allow improved tissue penetration. The compounds are selected from the group consisting of compounds of formula (i), or a pharmaceutically acceptable salt thereof: formula (i) wherein PDC is a photodynamic core and wherein R1; R2; R3; and R4 are H, phenyl, pyridine-4-yl, methylpyridinium, N-methylpyridinium-3-yl; 2-phenyl-N-methylpyridinium-4-yl, 3- phenyl-N-methylpyridinium-4-yl, 4-phenyl-N-methylpyridinium-4-yl, 2-phenyl-N- methylpyridinium-3-yl, 3-phenyl-N-methylpyridinium-3-yl or 4-phenyl-N- methylpyridinium-3-yl; and wherein any one or more of R1, R2, R3 and R4 may be optionally substituted.