2-benzhydryloxy-N,N-dimethylethanamine;(E)-but-2-enedioic acid | 114402-65-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzhydryloxy-N,N-dimethylethanamine;(E)-but-2-enedioic acid
• CAS: 114402-65-2
• 化学式: C21H25NO5
• 分子量: 371.4
• InChiKey: HTOPDYMCGZYYAS-WLHGVMLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• POROUS CELLULOSE AGGREGATE AND MOLDING COMPOSITION THEREOF
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1873196A1

  公开（公告）日：2008-01-02

  A porous cellulose aggregate characterized by having a secondary aggregate structure resulting from aggregation of primary cellulose particles, having a pore volume within a particle of 0.265 to 2.625 cm3/g, containing I-type crystals and having an average particle size of over 30 to 250 µm, a specific surface area of 0.1 to less than 20 m2/g, a repose angle of 25° to less than 44° and a swelling degree of 5% or more, and characterized by having the property of disintegrating in water.

  一种多孔纤维素聚合体，其特征在于具有由初级纤维素颗粒聚合而成的次级聚合体结构，颗粒内的孔隙体积为 0.265 至 2.625 cm3/g，含有 I 型晶体，平均粒径大于 30 至 250 µm，比表面积为 0.1 至小于 20 m2/g，倾角为 25 至小于 44°，膨胀度为 5%或以上，并具有遇水崩解的特性。
• CELLULOSE POWDER HAVING EXCELLENT SEGREGATION PREVENTIVE EFFECT, AND COMPOSITIONS THEREOF
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2287234A1

  公开（公告）日：2011-02-23

  With regard to compositions derived from active ingredients and other additives in medical, food and industrial fields, there have been problems that the active ingredients cannot be uniformly mixed, and that the active ingredients become segregated and lose uniformity as the active ingredients undergo transport, input, and filling processes. There is provided a cellulose powder which improves the uniformity of compositions containing active ingredients or other additives to prevent segregation of the active ingredients, wherein the cellulose powder contains cellulose I type crystals, has an average particle diameter of less than 30 µm, a powder density of 0.1 to 0.45 g/cm3, a tapping density of 0.1 to 0.5 g/cm3, a repose angle of 35 to 50°, a specific surface of more than or equal to 0.1 m2/g and less than 20 m2/g, an internal friction angle of 36 to 42°, and is a cellulose powder including a secondary flocculation structure in which primary particles are flocculated.

  关于医疗、食品和工业领域中由活性成分和其他添加剂制成的组合物，一直存在着活性成分不能均匀混合，以及活性成分在运输、输入和灌装过程中发生分离和失去均匀性的问题。本发明提供了一种纤维素粉末，可改善含有活性成分或其他添加剂的组合物的均匀性，防止活性成分的偏析，其中纤维素粉末含有纤维素 I 型晶体，平均颗粒直径小于 30 µm，粉末密度为 0.1至0.45克/立方厘米，攻丝密度为0.1至0.5克/立方厘米，倾伏角为35至50°，比表面大于或等于0.1平方米/克但小于20平方米/克，内摩擦角为36至42°，并且是一种纤维素粉末，包括二级絮凝结构，其中初级粒子被絮凝。
• COMPOSITE PARTICLES WHICH CONTAIN BOTH CELLULOSE AND INORGANIC COMPOUND
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2589618A1

  公开（公告）日：2013-05-08

  Provided are composite particles which exhibit excellent fluidity and high liquid retentivity and which exhibit high fluidity even in a liquid-holding sate. Also provided are composite particles which permit direct compressing in an open feed manner and which suffer from little compressing trouble and exhibit high shapability. When shaped together with an active ingredient, the composite particles provide shaped bodies which have uniform weight, uniform active ingredient content, and high hardness and which suffer from less galling.

  本发明提供的复合颗粒具有优异的流动性和高液体保持力，即使在液体保持状态下也能表现出高流动性。此外，还提供了可直接以开放式进料方式压缩的复合微粒，这种微粒几乎不会出现压缩问题，而且具有很高的成型性。当与活性成分一起成型时，复合颗粒可提供重量均匀、活性成分含量均匀、硬度高且不易咬合的成型体。
• COMPOSITE PARTICLES INCLUDING CELLULOSE, INORGANIC COMPOUND, AND HYDROXYPROPYL CELLULOSE
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3385306A1

  公开（公告）日：2018-10-10

  A composite particle comprising from 50 to 80 parts by mass of cellulose, from 10 to 40 parts by mass of an inorganic compound and from 4 to 11 parts by mass of hydroxypropyl cellulose based on 100 parts by mass of a total of contents of the cellulose, the inorganic compound and the hydroxypropyl cellulose.

  一种复合颗粒，以纤维素、无机化合物和羟丙基纤维素的总含量为 100 质量份为基准，由 50 至 80 质量份的纤维素、10 至 40 质量份的无机化合物和 4 至 11 质量份的羟丙基纤维素组成。
• CELLULOSE POWDER, USE THEREOF, AND TABLET
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3904429A1

  公开（公告）日：2021-11-03

  The present invention provides a cellulose powder containing an alkali-soluble substance capable of dissolving in 17.5% by mass of aqueous sodium hydroxide solution, the content of the alkali-soluble substance being 32% by mass or more and 44% by mass or less with respect to the total mass of the cellulose powder, the use thereof, and tablets using the same.

  本发明提供了一种含有碱溶性物质的纤维素粉末，该纤维素粉末能够溶解在 17.5% 质量的氢氧化钠水溶液中，其中碱溶性物质的含量为纤维素粉末总质量的 32% 或更多，44% 或更少；本发明还提供了纤维素粉末的用途及其片剂。