申请人:Eisai R&D Management Co., Ltd.
公开号:US07541376B2
公开(公告)日:2009-06-02
The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.
Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.
本发明提供了一种新型的1H-吲唑化合物,具有优异的JNK抑制作用。更具体地,它提供了以下公式所表示的化合物、其盐或其水合物。其中,R1是C6-C14芳香环烃基等;R2、R4和R5各自独立地表示氢原子、卤素原子、氰基等;L是单键或C1-C6烷基链等;X是单键或由—CO—NH—或—NH—CO—等表示的基团;而Y是C3-C8环烷基、C6-C14芳香环烃基或5-至14-成员芳香杂环基等。