4-(4-methylpyrimidin-2-yl)aniline | 474397-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-methylpyrimidin-2-yl)aniline
• CAS: 474397-16-5
• 化学式: C₁₁H₁₁N₃
• mdl: MFCD18330648
• 分子量: 185.228
• InChiKey: BTZGFOODEXURGK-UHFFFAOYSA-N

物化性质

• 沸点：
  268.6±32.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Dual inhibitorsof PDE 7 and PDE 4
  申请人：——

  公开号：US20030104974A1

  公开（公告）日：2003-06-05

  Dual inhibitors of PDE7 and PDE4, together with their use to treat leukocyte activation-associated disorders (including transplant rejection, rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, chronic obstructive pulmonary disease, lupus and multiple sclerosis), are provided herein.

  本文提供了PDE7和PDE4的双重抑制剂，以及它们用于治疗与白细胞激活相关的疾病（包括移植排斥、类风湿性关节炎、炎症性肠病、牛皮癣、哮喘、慢性阻塞性肺疾病、狼疮和多发性硬化症）的方法。
• NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF
  申请人：Korea Institute of Science and Technology

  公开号：EP3901139A1

  公开（公告）日：2021-10-27

  The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

  本发明涉及末端胺基被芳基或杂芳基取代的新型腙衍生物及其用途。
• NOVEL HYDRAZONE DERIVATIVE IN WHICH TERMINAL AMINE GROUP IS SUBSTITUTED WITH ARYL GROUP OR HETEROARYL GROUP, AND USE THEREOF
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20220396553A1

  公开（公告）日：2022-12-15

  The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.
• US6838559B2
  申请人：——

  公开号：US6838559B2

  公开（公告）日：2005-01-04
• [EN] NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF<br/>[FR] NOUVEAU DÉRIVÉ D'HYDRAZONE AVEC UN GROUPE ARYLE OU HÉTÉROARYLE SUBSTITUÉ AU NIVEAU D'UN GROUPE AMINE TERMINAL DE CELUI-CI ET SON UTILISATION<br/>[KO] 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
  申请人：KOREA INST SCI & TECH

  公开号：WO2020130214A1

  公开（公告）日：2020-06-25

  본 발명은 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체(hydrazone derivatives) 및 이의 용도에 관한 것이다.