Chloroform pyridine | 18675-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Chloroform pyridine
• 英文别名: chloroform;pyridine
• CAS: 18675-83-7
• 化学式: C6H6Cl3N
• 分子量: 198.5
• InChiKey: JEIJBKDXJPNHGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(3-Chloro-phenyl)-5-(4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole 、 Chloroform pyridine 、 溴 在 氯化铵 、 Sodium sulfate-III 、 乙醚 作用下， 以 氯仿 为溶剂， 反应 16.0h， 以to give the title compound (1.5 g, 57.5%, yellow solid)的产率得到5-(5-bromo-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(3-chloro-phenyl)-[1,2,4]oxadiazole
  参考文献：
  名称：

  ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS

  摘要：

  本发明涉及公式I的新化合物，包含该化合物的制药配方以及在预防和/或治疗mGluR5受体介导的疾病中使用该化合物的方法。

  公开号：

  US20080015234A1
• 作为试剂：
  描述：

  、 吗啉 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 碳酸氢钠 在 ice 、 氯仿 、 Brine 、 Sodium sulfate-III 作用下， 以 Chloroform pyridine 为溶剂， 反应 17.0h， 以to give the title compound (174 mg)的产率得到
  参考文献：
  名称：

  Carbamoyl-type benzofuran derivatives

  摘要：

  本发明提供了一种公式[1]的氨基甲酰基苯并呋喃衍生物： 其中，环Z是公式等的一组；A是单键等；Y是环烷基二基等；R4和R5相同或不同，每个是可选取的低取代基等；R1是卤素原子等；环B是可选取的苯环；R3是氢原子等；或其药学上可接受的盐，作为FXa抑制剂具有用处。

  公开号：

  US20060247273A1

文献信息

• FATTY ACID DERIVATIVES
  申请人：——

  公开号：US20010006962A1

  公开（公告）日：2001-07-05

  The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and carboxylic acid ester groups are modified by replacing one or more of these functional groups by a lipophilic group selected from those of the formula: RCOO—, RCONH—, RCOS—, RCH 2 O—, RCH 2 NH—, —COOCH 2 R, —CONHCH 2 R and —SCH 2 R, wherein R is a lipophilic moiety selected from cis-8-heptadecenyl, trans-8-heptadecenyl, cis-10-nonadecenyl and trans-10-nonadecenyl.

  生物活性化合物（例如药物和农药）的性质，其中分子结构中包含来自醇、醚、苯基、氨基、酰胺、硫醇、羧酸和羧酸酯基团中的一个或多个官能团，通过用来自以下公式的亲脂基团替换其中一个或多个这些官能团来进行修改：RCOO—、RCONH—、RCOS—、RCH2O—、RCH2NH—、—COOCH2R、—CONHCH2R和—SCH2R，其中R是从顺式-8-十七碳烯基、反式-8-十七碳烯基、顺式-10-十九碳烯基和反式-10-十九碳烯基中选择的亲脂基团。
• Novel nucleic acid base pair
  申请人：Hirao Ichiro

  公开号：US20050191689A1

  公开（公告）日：2005-09-01

  A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static repulsion and a stacking effect) and can be recognized by a polymerase such as DNA polymerase; a novel artificial gene; and a method of designing nucleic acid bases so as to form a selective base pair with the use of steric hindrance, static repulsion and stacking effect at the base moiety of the nucleic acid. An artificial nucleic acid comprising these bases; a process for producing the same; a codon containing the same; a nucleic acid molecule containing the same; a process for producing a non-natural gene by using the same; a process for producing a novel protein by using the above nucleic acid molecule or non-natural gene, and the like.

  一种新的人工核酸碱基对，通过引入具有立体位阻的基团（优选具有立体位阻和静电斥力以及堆积效应的基团），形成选择性碱基对，并能被DNA聚合酶等聚合酶识别；一种新的人工基因；以及一种设计核酸碱基的方法，以便利用核酸的碱基部分的立体位阻、静电斥力和堆积效应形成选择性碱基对。包括这些碱基的人工核酸；生产该核酸的过程；含有该核酸的密码子；含有该核酸的核酸分子；利用该核酸分子或非天然基因生产非天然基因的过程；利用上述核酸分子或非天然基因生产新型蛋白质的过程等。
• Synthesis, spectroscopy, photophysics of multi-chromophoric Zn(II) group 8 metal complexes
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20040152826A1

  公开（公告）日：2004-08-05

  Novel multichromophoric complexes comprising the formula R 1 —R A -[MC]—([R M ] z —[MC]) m -RA—R 2 are provided. Polymeric compositions and devices comprising the same are also discussed. The complexes are characterized by a central bridging moiety comprising one or a plurality of linked conjugated macrocyclic molecules [MC] coupled to at least one inorganic moiety (R 1 and/or R 2 ) through organic linker R A . Preparation methods include metal-mediated cross-coupling techniques. The complexes can be useful in nonlinear optical devices and other optoelectronic applications.

  提供了由公式R1-RA-[MC]-([RM]z-[MC])m-RA-R2组成的新型多色团复合物。还讨论了包含这些复合物的聚合物组合物和设备。这些复合物的特点是由一个或多个连接的共轭大环分子[MC]组成的中央桥接基团，通过有机连接剂RA与至少一个无机基团（R1和/或R2）耦合。制备方法包括金属介导的交叉偶联技术。这些复合物可以在非线性光学器件和其他光电应用中发挥作用。
• Fatty acid derivatives
  申请人：——

  公开号：US20030153544A1

  公开（公告）日：2003-08-14

  The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and carboxylic acid ester groups are modified by replacing one or more of these functional groups by a lipophilic group selected from those of the formula: RCOO—, RCONH—, RCOS—, RCH 2 O—, RCH 2 NH—, —COOCH 2 R, —CONHCH 2 R and —SCH 2 R, wherein R is a lipophilic moiety selected from cis-8-heptadecenyl, trans-8-heptadecenyl, cis-10-nonadecenyl and trans-10-nonadecenyl.

  含有醇、醚、苯基、氨基、酰胺、巯基、羧酸和羧酸酯等分子结构中的一个或多个官能团的生物活性化合物，例如药物和农药，通过用以下公式中的亲脂基替换其中一个或多个官能团来改变其性质：RCOO—、RCONH—、RCOS—、RCH 2 O—、RCH 2 NH—、—COOCH 2 R、—CONHCH 2 R 和—SCH 2 R，其中R是从顺式-8-十七烯基、反式-8-十七烯基、顺式-10-十九烯基和反式-10-十九烯基中选择的亲脂基。
• Methods of treating disorders using lipophilic derivatives
  申请人：Norsk Hydro ASA

  公开号：US20040063677A1

  公开（公告）日：2004-04-01

  The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and carboxylic acid ester groups are modified by replacing one or more of these functional groups by a lipophilic group selected from those of the formula: RCOO—, RCONH—, RCOS—, RCH 2 O—, RCH 2 NH—, —COOCH 2 R, —CONHCH 2 R and —SCH 2 R, wherein R is a lipophilic moiety selected from cis-8-heptadecenyl, trans-8-heptadecenyl, cis-10-nonadecenyl and trans-10-nonadecenyl.

  含有醇、醚、苯基、氨基、酰胺、巯基、羧酸和羧酸酯等功能基团的生物活性化合物（例如药物和农药），可以通过用公式为RCOO—、RCONH—、RCOS—、RCH2O—、RCH2NH—、—COOCH2R、—CONHCH2R和—SCH2R的亲脂基团替换其中一个或多个功能基团来改变其性质，其中R是从顺式-8-十七烯基、反式-8-十七烯基、顺式-10-十九烯基和反式-10-十九烯基中选择的亲脂基团。