2-(3-Phenylprop-2-enylamino)benzonitrile | 1293330-38-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Phenylprop-2-enylamino)benzonitrile
• 英文别名: 2-(3-phenylprop-2-enylamino)benzonitrile
• CAS: 1293330-38-7
• 化学式: C₁₆H₁₄N₂
• mdl: MFCD17056836
• 分子量: 234.301
• InChiKey: DTXNNJVQVLXNRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.062
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-苯基-1-丙炔 、 2-氨基苯甲腈 在 苯甲酸 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以82%的产率得到2-(3-Phenylprop-2-enylamino)benzonitrile
  参考文献：
  名称：

  Allylation of 1-phenyl-1-propyne with N- and O-pronucleophiles using polymer supported triphenylphosphine palladium complex as a heterogeneous and recyclable catalyst

  摘要：

  Simple methodology for the allylation of various N- and O-pronucleophiles with 1-phenyl-1-propyne as an allylating agent, using PS-TPP-Pd (polymer supported triphenylphosphine palladium) as a highly active heterogeneous recyclable catalyst has been developed. The protocol is applicable for a wide variety of hindered and functionalized aromatic amines, alcohols, and carboxylic acids. The catalyst exhibited remarkable catalytic activity for five consecutive recycles. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.099

文献信息

• Pd(OAc)2/dppf as an efficient and highly active catalyst for the allylation of amines, alcohols and carboxylic acids with 1-phenyl-1-propyne
  作者：Yogesh S. Wagh、Dinesh N. Sawant、Pawan J. Tambade、Kishor P. Dhake、Bhalchandra M. Bhanage

  DOI：10.1016/j.tet.2011.02.008

  日期：2011.4

  Pd(OAc)(2)/1,1'-bis(diphenylphosphino)ferrocene as an efficient, highly active catalyst for the allylation of amines, alcohols and carboxylic acids with 1-phenyl-1-propyne has been developed. The effect of various reaction parameters, such as ligand, time, solvent, temperature, metal: ligand ratio and catalyst concentration on yields of the product were investigated. The optimized procedure works well under mild operating conditions and permits rapid generation of a library for various allylated products. (C) 2011 Elsevier Ltd. All rights reserved.
• Allylation of 1-phenyl-1-propyne with N- and O-pronucleophiles using polymer supported triphenylphosphine palladium complex as a heterogeneous and recyclable catalyst
  作者：Yogesh S. Wagh、Dinesh N. Sawant、Kishor P. Dhake、Krishna M. Deshmukh、Bhalchandra M. Bhanage

  DOI：10.1016/j.tetlet.2011.08.099

  日期：2011.10

  Simple methodology for the allylation of various N- and O-pronucleophiles with 1-phenyl-1-propyne as an allylating agent, using PS-TPP-Pd (polymer supported triphenylphosphine palladium) as a highly active heterogeneous recyclable catalyst has been developed. The protocol is applicable for a wide variety of hindered and functionalized aromatic amines, alcohols, and carboxylic acids. The catalyst exhibited remarkable catalytic activity for five consecutive recycles. (C) 2011 Elsevier Ltd. All rights reserved.