1-Methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol;hydrochloride | 34758-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol;hydrochloride
• CAS: 34758-84-4
• 化学式: C23H33ClN2O3
• 分子量: 421.0
• InChiKey: GBXWNMWMUOJDKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.16
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• chewing gum in the form of multi-layer tablets
  申请人：CROSS CHEM LLC

  公开号：EP1449525A1

  公开（公告）日：2004-08-25

  Disclosed are tablets comprising at least one inner layer of gum base containing one or more active pharmaceutical, dietetic or nutritional ingredients and at least one outer layer comprising excipients/compression adjuvants and possibly active ingredients which are the same as or different from those present in the inner layer. Said tablets are obtainable by direct compression of mixtures or granulates of the various components of each layer.

  所公开的片剂包括至少一层胶基内层和至少一层外层，前者含有一种或多种活性药物、饮食或营养成分，后者含有辅料/压缩佐剂以及可能与内层相同或不同的活性成分。 所述药片可通过直接压缩各层各种成分的混合物或颗粒来获得。
• Chewing gum in the form of multi-layer tablets
  申请人：Salini Alberto

  公开号：US20060204451A1

  公开（公告）日：2006-09-14

  Disclosed are tablets having a sandwich-like structure comprising at least one inner layer of gum base containing one or more active pharmaceutical, dietetic or nutritional ingredients and two non-contigous outer layers comprising antiadhesion excipients and compression adjuvants preventing the adhesion to the punches of the tabletting machine and possibly active ingredients which are the same as or different from those present in the inner layer. Said tablets are obtainable by direct compression of mixtures or granulates of the various components of each layer.

  所公开的片剂具有类似三明治的结构，包括至少一层含有一种或多种活性药物、膳食或营养成分的胶基内层和两层不相邻的外层，外层含有防止粘附到压片机冲头的抗粘附辅料和压缩佐剂，以及可能与内层相同或不同的活性成分。所述片剂可通过直接压缩各层不同成分的混合物或颗粒来获得。
• CHEWING GUM IN THE FORM OF MULTI-LAYER TABLETS
  申请人：JAGOTEC AG

  公开号：EP1594478A1

  公开（公告）日：2005-11-16
• US9216157B2
  申请人：——

  公开号：US9216157B2

  公开（公告）日：2015-12-22
• [EN] CHEWING GUM IN THE FORM OF MULTI-LAYER TABLETS<br/>[FR] GOMME A MACHER SE PRESENTANT SOUS LA FORME DE TABLETTES MULTICOUCHE
  申请人：FLARER S A

  公开号：WO2004073691A1

  公开（公告）日：2004-09-02

  Disclosed are tablets having a sandwich-like structure comprising at least one inner layer of gum base containing one or more active pharmaceutical, dietetic or nutritional ingredients and twonon-contigous outer layers comprising antiadhesion excipients and compression adjuvants preventing the adhesion to the punches of the tabletting machine and possibly active ingredients which are the same as or different from those present in the inner layer. Said tablets are obtainable by direct compression of mixtures or granulates of the various components of each layer.