Carbamic acid, [1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]propyl]-, 1,1-dimethylethyl ester | 304020-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Carbamic acid, [1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]propyl]-, 1,1-dimethylethyl ester
• 英文别名: 2-[(2-methylpropan-2-yl)oxycarbonylamino]butyl 4-methylbenzenesulfonate
• CAS: 304020-69-7
• 化学式: C₁₆H₂₅NO₅S
• 分子量: 343.4
• InChiKey: BWSUHGQXPNUWPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] 5,7-BICYCLIC AMIDINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] DERIVES D'AMIDINE 5,7-BICYCLIQUE UTILES EN TANT QU'INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE
  申请人：ASTRAZENECA AB

  公开号：WO2000064904A1

  公开（公告）日：2000-11-02

  There are provided novel compounds of formula (I), wherein R?1, R2, R3, R4, R5, R6, R12¿, A, B, D and X are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.