<2-Piperidino-ethyl>--ether | 102372-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <2-Piperidino-ethyl>--ether
• 英文别名: 1-[2-(4-methyl-benzhydryloxy)-ethyl]-piperidine；1-[2-(4-Methyl-benzhydryloxy)-aethyl]-piperidin；1-[2-[(4-Methylphenyl)-phenylmethoxy]ethyl]piperidine
• CAS: 102372-26-9
• 化学式: C₂₁H₂₇NO
• 分子量: 309.451
• InChiKey: ZIMMXYLZQHHFOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  <2-Piperidino-ethyl>--ether 、 碘甲烷 生成 1-methyl-1-[2-(4-methyl-benzhydryloxy)-ethyl]-piperidinium; iodide
  参考文献：
  名称：

  Borovicka; Vondracek, Chemicke Listy, 1949, vol. 43, p. 261,263

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(2-氯乙基)哌啶 、 alkaline earth salt of/the/ methylsulfuric acid 在 xylene 作用下， 生成 <2-Piperidino-ethyl>--ether
  参考文献：
  名称：

  Borovicka; Vondracek, Chemicke Listy, 1949, vol. 43, p. 261,263

  摘要：

  DOI：

文献信息

• Protiva; Borovicka, Collection of Czechoslovak Chemical Communications, 1948, vol. 13, p. 582
  作者：Protiva、Borovicka

  DOI：——

  日期：——
• Methods and Compositions for Treating Degenerative and Ischemic Disorders
  申请人：The General Hospital Corporation

  公开号：US20160324850A1

  公开（公告）日：2016-11-10

  Model systems have shown that shifting a cell's reliance from oxidative phosphorylation (OXPHOS) to glycolysis can protect against cell death. Exploiting the therapeutic potential of this strategy, however, has been limited by the lack of clinically safe agents that remodel energy metabolism. The present invention identifies non-toxic small molecules (e.g., drug-like compounds) that are capable of modulating oxidative metabolism. One identified compound comprises meclizine. As described herein, meclizine, and its enantiomer S-meclizine, redirects OXPHOS to glycolysis. Such compounds could be protective or therapeutic in degenerative disorders such as diabetes, Huntington's, Parkinson's, and Alzheimer's disease and/or ischemic disorders including, but not limited to, stroke, heart attack, or reperfusion injuries.
• US9399032B2
  申请人：——

  公开号：US9399032B2

  公开（公告）日：2016-07-26
• Borovicka; Vondracek, Chemicke Listy, 1949, vol. 43, p. 261,263
  作者：Borovicka、Vondracek

  DOI：——

  日期：——