3-Nitro-5-(trifluoromethyl)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Nitro-5-(trifluoromethyl)benzoate
• 化学式: C8H3F3NO4-
• 分子量: 234.11
• InChiKey: ODCLHXGXGFBBTA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  86
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS
  申请人：Bissantz Caterina

  公开号：US20120232051A1

  公开（公告）日：2012-09-13

  This invention relates to novel 3-aminopyridines of the formula wherein B 1 , B 2 and R 1 to R 6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

  这项发明涉及以下结构的新型3-氨基吡啶： 其中B1、B2和R1至R6如描述和索赔中所定义，并且其药学上可接受的盐。这些化合物是GPBAR1激动剂，可用作治疗诸如2型糖尿病等疾病的药物。
• Systems and methods for delivery of materials
  申请人：Landec Corporation

  公开号：EP2502619A2

  公开（公告）日：2012-09-26

  A release composition for agricultural applications which comprises an ECC polymer and a release material associated with the ECC polymer, wherein the release material is a fertilizer, biocide, insecticide or fungicide, and wherein the ECC polymer is defined as a polymer (A) which comprises polymeric molecules having a backbone and comprising at least one moiety which has the formula -b-Cy, wherein the -b-Cy moiety either (a) forms part of a repeating unit of the backbone, the repeating unit having the formula (1) below where Ych is a moiety forming part of the backbone, b is a bond or moiety which links the Cy moiety to Ych, and Cy is a moiety which is associated with other moieties to provide the ECC polymer with crystallinity, or (b) forms part of a terminal unit of the backbone, the terminal unit having the formula (2) below          -Yterm- b-Cy     (2) where Yterm is a moiety at the end of the backbone, and b and Cy are as defined in formula (1); (B) in which at least 50% by weight of the Cy moieties are present in terminal units of formula (2); and (C) which has a crystalline melting temperature, Tp, of at least 0°C and a ΔH of at least 3J/g which results from association of the Cy moieties.

  一种用于农业应用的释放组合物，它包括 ECC 聚合物和与 ECC 聚合物相关的释放材料、 其中释放材料为肥料、杀菌剂、杀虫剂或杀真菌剂，ECC 聚合物定义为聚合物 (A) 由具有骨架的聚合物分子组成，至少包含一个分子式为-b-Cy 的分子，其中-b-Cy 分子可以是 (a) 构成骨架重复单元的一部分，该重复单元具有下式(1) 其中 Ych 是构成骨架一部分的分子，b 是连接 Cy 分子和 Ych 的键或分子，Cy 是与其他分子相连的分子，使 ECC 聚合物具有结晶性、 或 (b) 构成骨架末端单元的一部分，末端单元具有下式 (2) -Yterm- b-Cy (2) 其中 Yterm 是位于骨架末端的分子，b 和 Cy 如式（1）中所定义； (B) 其中至少 50%（按重量计）的 Cy 分子存在于式（2）的末端单元中；以及 (C) 其结晶熔化温度 Tp 至少为 0℃，Cy 分子结合产生的 ΔH 至少为 3J/g。
• 3-amino-pyridines as GPBAR1 agonists
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US10385022B2

  公开（公告）日：2019-08-20

  This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

  本发明涉及新型 3-氨基吡啶，其式为 其中 B1、B2 和 R1 至 R6 如说明书和权利要求书中所定义，以及其药学上可接受的盐类。这些化合物是 GPBAR1 激动剂，可用作治疗 II 型糖尿病等疾病的药物。
• Compositions and methods for personal care
  申请人：Bitler Steven P.

  公开号：US20090246155A1

  公开（公告）日：2009-10-01

  Systems and methods for delivering personal care materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the cosmetic materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable.
• Systems and methods for delivery of drugs
  申请人：Taft David

  公开号：US20090263346A1

  公开（公告）日：2009-10-22

  Systems and methods for delivering drugs. Crystalline polymeric systems, referred to as CYC carriers, are associated with the drugs, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable.