5-Methylpyridine-2,6(1H,3H)-dione | 72692-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Methylpyridine-2,6(1H,3H)-dione
• 英文别名: 5-methyl-3H-pyridine-2,6-dione
• CAS: 72692-94-5
• 化学式: C₆H₇NO₂
• 分子量: 125.13
• InChiKey: XRYNRKOHRFLIGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 6-MEMBERED URACIL ISOSTERES<br/>[FR] ISOSTÈRES D'URACILE À 6 CHAÎNONS
  申请人：CV6 THERAPEUTICS NI LTD

  公开号：WO2018098204A1

  公开（公告）日：2018-05-31

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

  本文件提供了dUTPase抑制剂，包含此类化合物的组合物以及使用此类化合物和组合物的方法。
• ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES
  申请人：BIOCRYST PHARMACEUTICALS, INC.

  公开号：US20150291596A1

  公开（公告）日：2015-10-15

  Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.

  本发明涉及一种含有偶氮糖与杂环碱基结合的化合物，包括其药学上可接受的盐，适用于抑制病毒RNA聚合酶活性或病毒复制，并用于治疗病毒感染。该化合物的特点之一是具有良好的药代动力学，特别是在肠道给药的情况下，包括口服给药。本发明还涉及含有上述一种或多种化合物或其药学上可接受的盐的制药组合物，以及制备它们的方法。本发明还提供了抑制病毒RNA聚合酶活性、病毒复制和治疗病毒感染的方法。
• AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF
  申请人：Genoa Pharmaceuticals, Inc.

  公开号：EP2670242A1

  公开（公告）日：2013-12-11
• AZACYTIDINE ANALOGUES AND USES THEREOF
  申请人：SILVERMAN Lewis

  公开号：US20090209482A1

  公开（公告）日：2009-08-20

  The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R 5 C(O); R 1 is where the crossing dashed line illustrates the bond formed joining R 1 to the molecule of Formula (I); R 2 and R 3 are independently OH or H, provided that R 2 and R 3 are not simultaneously OH; R 4 is H or R 5 C(O), provided that R and R 4 are not simultaneously H; and R 5 is a C 3 -C 26 alkenyl, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
• THE USE OF 6-HALOGENO-[1,2,4]-TRIAZOLO-[1,5-a]-PYRIMIDINE COMPOUNDS FOR COMBATING PESTS IN AND ON ANIMALS
  申请人：Baumann Ernst

  公开号：US20110028495A1

  公开（公告）日：2011-02-03

  The present invention relates to the use of 6-halogeno-[1,2,4]-triazolo[1,5-a]-pyrimidine compounds of the general formula I wherein A, R 1 , R 2 , R 3 and R 4 are as defined in the specification; and/or an enantiomer, diastereomer, tautomer, solvate, crystalline form or veterinarily acceptable salt thereof alone or in combination with an additional anti-parasiticidal agent for combating parasites in and on animals.