3-(dipropylamino)-7-thiomorpholinophenoxazin-5-ium chloride | 1032716-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 3-(dipropylamino)-7-thiomorpholinophenoxazin-5-ium chloride
• 英文别名: N,N-dipropyl-7-thiomorpholin-4-ium-4-ylidenephenoxazin-3-amine;chloride
• CAS: 1032716-36-1
• 化学式: C₂₂H₂₈N₃OS*Cl
• 分子量: 418.003
• InChiKey: HVEWQUCLXMDJOB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(3-methoxy-4-nitrosophenyl)thiomorpholine 、 3-(dipropylamino)phenol 在 盐酸 作用下， 以 水 、 异丙醇 为溶剂， 反应 4.0h， 以55%的产率得到3-(dipropylamino)-7-thiomorpholinophenoxazin-5-ium chloride
  参考文献：
  名称：

  Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives

  摘要：

  3,7-Bis(dialkylamino)phenoxazinium salts were synthesized and evaluated for in vitro activities against Plasmodium falciparum, Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani. Notably, the compounds showed potent antiprotozoal activities, especially against P. falciparum and T cruzi. The compounds with alkyl side chains less than three carbons in length possessed good activities with high selective indices.

  DOI：

  10.1021/jm8003619

文献信息

• Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives
  作者：Jian-Feng Ge、Chika Arai、Marcel Kaiser、Sergio Wittlin、Reto Brun、Masataka Ihara

  DOI：10.1021/jm8003619

  日期：2008.6.1

  3,7-Bis(dialkylamino)phenoxazinium salts were synthesized and evaluated for in vitro activities against Plasmodium falciparum, Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani. Notably, the compounds showed potent antiprotozoal activities, especially against P. falciparum and T cruzi. The compounds with alkyl side chains less than three carbons in length possessed good activities with high selective indices.