N-(4-aminophenyl)sulfonyl-4-(4-bromophenyl)-N-octylbenzenesulfonamide | 1021190-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-aminophenyl)sulfonyl-4-(4-bromophenyl)-N-octylbenzenesulfonamide
• CAS: 1021190-55-5
• 化学式: C₂₆H₃₁BrN₂O₄S₂
• 分子量: 579.579
• InChiKey: MVAHDNKGZFKLKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(4-aminophenyl)sulfonyl-4-(4-bromophenyl)-N-octylbenzenesulfonamide 、 对硝基苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以60%的产率得到
  参考文献：
  名称：

  Persulfonylation of Amines Applied to the Synthesis of Higher Generation Dendrimers

  摘要：

  Systematic analysis of the persulfonylation of branched aromatic oligoamines with different arylsulfonyl chlorides allowed optimization of the repetitive steps involved in the synthesis of the sulfonimide-based dendrimers. The optimized procedures afforded the fourth generation N- and pentaphenylene-centered dendrimers with 16 and 32 peripheral groups, respectively. Analysis of products of incomplete substitution showed that the amino groups in aromatic oligoamines are persulfonylated consecutively.

  DOI：

  10.1021/jo800179m
• 作为产物：
  描述：

  4'-bromo-N-((4-nitrophenyl)sulfonyl)-N-octyl-[1,1'-biphenyl]-4-sulfonamide 在 盐酸 、 tin(ll) chloride 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以91%的产率得到N-(4-aminophenyl)sulfonyl-4-(4-bromophenyl)-N-octylbenzenesulfonamide
  参考文献：
  名称：

  Persulfonylation of Amines Applied to the Synthesis of Higher Generation Dendrimers

  摘要：

  Systematic analysis of the persulfonylation of branched aromatic oligoamines with different arylsulfonyl chlorides allowed optimization of the repetitive steps involved in the synthesis of the sulfonimide-based dendrimers. The optimized procedures afforded the fourth generation N- and pentaphenylene-centered dendrimers with 16 and 32 peripheral groups, respectively. Analysis of products of incomplete substitution showed that the amino groups in aromatic oligoamines are persulfonylated consecutively.

  DOI：

  10.1021/jo800179m

文献信息

• Persulfonylation of Amines Applied to the Synthesis of Higher Generation Dendrimers
  作者：Oleg Lukin、Dirk Schubert、Claudia Müller、Mirza Corda、Ramchandra Kandre

  DOI：10.1021/jo800179m

  日期：2008.5.1

  Systematic analysis of the persulfonylation of branched aromatic oligoamines with different arylsulfonyl chlorides allowed optimization of the repetitive steps involved in the synthesis of the sulfonimide-based dendrimers. The optimized procedures afforded the fourth generation N- and pentaphenylene-centered dendrimers with 16 and 32 peripheral groups, respectively. Analysis of products of incomplete substitution showed that the amino groups in aromatic oligoamines are persulfonylated consecutively.