Hydroxypyridinone derivatives, metal complexes thereof and the use thereof for preparing conjugates with biomolecules
申请人:Schmitt-Willich Heribert
公开号:US20070003484A1
公开(公告)日:2007-01-04
The invention relates to hydroxypyridinone derivatives, their metal complexes, their preparation and their use for preparing conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
该发明涉及羟基吡啶酮衍生物,它们的金属配合物,它们的制备以及它们用于与生物分子制备共轭物的用途。这些共轭物适用于核磁共振诊断中的对比剂。通过特定的配体设计实现高弛豫率,并提高核磁共振弛豫率分布最大值。