1,3-bis(fluoromethyl)benzene | 921595-53-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-bis(fluoromethyl)benzene
• 英文别名: 1,3-di(fluoromethyl)benzene；m-xylylenedifluoride
• CAS: 921595-53-1
• 化学式: C₈H₈F₂
• 分子量: 142.148
• InChiKey: CSWGHVOWBGYQII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  间二溴苄 在 18-冠醚-6 potassium fluoride 作用下， 以 乙腈 为溶剂， 反应 72.0h， 生成 1,3-bis(fluoromethyl)benzene
  参考文献：
  名称：

  Interbenzylic19F,19F spin-spin coupling constants in bis(fluoromethyl) arenes

  摘要：

  AbstractFive‐ to eleven‐bond F,F spin coupling is observed in bis(fluoromethyl)arenes. According to INDO MO calculations, these couplings are transmitted mainly via the aromatic π‐system. The low preference of 1,4‐(CH2F)2‐benzene for the conformation in which the CF bonds are perpendicular to the aromatic ring is shown by the strong increase of7J(FF) upon double ortho‐substitution.

  DOI：

  10.1002/mrc.1270160117

文献信息

• Pentafluoroethylating compositions
  申请人：Fundació Institut Català d'Investigació Química

  公开号：EP2835374A1

  公开（公告）日：2015-02-11

  The present invention relates to pentafluoroethylating compositions, processes for obtaining them, and their use in pentafluoroethylation reactions.

  本发明涉及五氟乙基化组合物，获取它们的过程，以及它们在五氟乙基化反应中的应用。
• CURABLE COMPOSITION FOR IMPRINT, PATTERNING METHOD AND PATTERN
  申请人：Kodama Kunihiko

  公开号：US20110059302A1

  公开（公告）日：2011-03-10

  A curable composition for imprints, which is excellent in patternability and in line edge roughness, is provided. The curable composition for imprints comprises at least one kind of polymerizable monomer (A) and at least one kind of photopolymerization initiator (B). The polymerizable monomer (A) comprises at least two fluorine-containing groups selected from a fluoroalkyl group and a fluoroalkylether group and each of two of the fluorine-containing groups is connected with each other through a linking group having at least two carbon atoms.

  提供了一种可治愈的印迹组合物，其在图案化和线边粗糙度方面表现出色。该可固化的印迹组合物包括至少一种聚合单体（A）和至少一种光聚合引发剂（B）。聚合单体（A）包括至少两种含氟基团，所选基团为氟烷基或氟烷基醚基，其中每两个含氟基团通过具有至少两个碳原子的连接基团相互连接。
• [EN] HALOALUMINOXANE COMPOSITIONS, THEIR PREPARATION, AND THEIR USE IN CATALYSIS<br/>[FR] COMPOSITIONS D'HALOALUMINOXANE, PREPARATION ET UTILISATION DE CELLES-CI DANS DES CATALYSES
  申请人：ALBEMARLE CORP

  公开号：WO2005066191A1

  公开（公告）日：2005-07-21

  Novel haloaluminoxane compositions have been formed. The halogen is fluorine, chlorine, and/or bromine, and the amount of halogen atoms present in said composition is in the range of about 0.5 mole % to about 15 mole % relative to aluminum atoms.

  已经形成了新的氧化铝卤代铝簇合物。卤素可以是氟、氯和/或溴，而该簇合物中存在的卤素原子的数量在相对于铝原子约0.5摩尔％至约15摩尔％的范围内。
• Aromatic amine resins, their production process and thermosetting resin compositions making use of the same
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0311387A2

  公开（公告）日：1989-04-12

  Disclosed herein is an aromatic amine resin formed of a mixture of aromatic amine compounds represented by the following general formula (a): wherein A means a phenylene, alkyl-substituted phenylene, diphenylene, diphenyl ether or naphthylenyl group, R¹ denotes a halogen atom or a hydroxyl, C1-4 alkoxy or C1-5 alkyl group, ℓ stands for 1 or 2, m is an integer of 0-3, when m is 2 or 3, R¹s may be the same or different and two of R¹s may join together into a 5- to 6-membered alicyclic moiety which may optionally contain one or more side chains, and n stands for an integer of 0-300.

  本发明公开了一种芳香胺树脂，该树脂由以下通式(a)代表的芳香胺化合物混合物形成： 其中 A 表示亚苯基、烷基取代亚苯基、二苯基、二苯醚或萘基，R¹ 表示卤素原子或羟基、C1-4 烷氧基或 C1-5 烷基，ℓ 表示 1 或 2，m 为 0-3 的整数、当 m 为 2 或 3 时，R¹ 可相同或不同，两个 R¹ 可连接成 5 至 6 元脂环分子，该分子可选择包含一条或多条侧链，n 代表 0 至 300 的整数。
• Substituted triazole diamine derivatives as kinase inhibitors
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1712550A2

  公开（公告）日：2006-10-18

  Use of substituted triazole diamine derivatives in the manufacture of a medicament for the treatment of a kinase mediated disorder wherein the disorder is mediated by the selective inhibition of at least one kinase selected from cyclin dependent kinase and a tyrosine kinase.

  使用取代的三唑二胺衍生物制造治疗激酶介导的疾病的药物，其中该疾病是通过选择性抑制至少一种选自细胞周期蛋白依赖性激酶和酪氨酸激酶的激酶而介导的。