11-guanidinodrimene | 1048331-50-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 11-guanidinodrimene
• 英文别名: 2-[[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]methyl]guanidine
• CAS: 1048331-50-5
• 化学式: C₁₆H₂₉N₃
• 分子量: 263.426
• InChiKey: BTQGCECTNUKHBE-HEHGZKQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  sodium cyanamide 、 11-aminodrim-7-ene 在 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 以81%的产率得到11-guanidinodrimene
  参考文献：
  名称：

  Synthesis of a new nitrogenated drimane derivative with antifungal activity

  摘要：

  Drimane sesquiterpenes are highly valuable due to their strong biological activity. In this Work, we report the enhanced antifungal activity of 11 -guanidinodrimene, a new compound derived from drimenol. The binding of the guanidine group at the C-I I carbon increased the antifungal activity when tested against Candida albicans, one of the most commonly found human pathogens. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.092

文献信息

• Synthesis of a new nitrogenated drimane derivative with antifungal activity
  作者：Miguel Zárraga、Ana María Zárraga、Benito Rodríguez、Claudia Pérez、Cristian Paz、Pablo Paz、Carlos Sanhueza

  DOI：10.1016/j.tetlet.2008.05.092

  日期：2008.8

  Drimane sesquiterpenes are highly valuable due to their strong biological activity. In this Work, we report the enhanced antifungal activity of 11 -guanidinodrimene, a new compound derived from drimenol. The binding of the guanidine group at the C-I I carbon increased the antifungal activity when tested against Candida albicans, one of the most commonly found human pathogens. (C) 2008 Elsevier Ltd. All rights reserved.