N-benzoyl-D-arginine 2-naphthylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoyl-D-arginine 2-naphthylamide
• 英文别名: N-[(2R)-5-(diaminomethylideneamino)-1-(naphthalen-2-ylamino)-1-oxopentan-2-yl]benzamide
• 化学式: C₂₃H₂₅N₅O₂
• 分子量: 403.5
• InChiKey: DEFAKPKFXYITPZ-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Dental diagnostic device and method
  申请人：DENTSPLY MANAGEMENT CORP.

  公开号：EP0304871A2

  公开（公告）日：1989-03-01

  An apparatus for use in dental diagnosis of a root canal and of periodontal pockets is provided. The apparatus comprises a device for absorbing fluids in the oral cavity and a handle for carrying the device to the oral cavity without contaminating the device by touching it with the fingers. The device of the invention comprises an absorbent material (26), adapted to be inserted into a root canal or a periodontal pocket, which has a substrate absorbed thereon which reacts with enzymes which are indicative of disease in the oral cavity. A detectable change in fluorescence or color in the substrate indicates the presence of the enzymes. A method of using the device of the invention to detect the presence of bacteria or disease in the oral cavity is also provided.

  提供了一种用于牙科诊断根管和牙周袋的仪器。该设备包括一个用于吸收口腔内液体的装置和一个用于将该装置携带至口腔而不会因手指接触而污染该装置的手柄。本发明的装置包括一种可插入根管或牙周袋的吸收材料 (26)，其上吸收有一种基质，该基质会与指示口腔疾病的酶发生反应。基质中可检测到的荧光或颜色变化表明酶的存在。还提供了一种使用本发明装置检测口腔中是否存在细菌或疾病的方法。