N-benzoyl-L-arginine 2-naphthylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoyl-L-arginine 2-naphthylamide
• 英文别名: N-[(2S)-5-(diaminomethylideneamino)-1-(naphthalen-2-ylamino)-1-oxopentan-2-yl]benzamide
• 化学式: C₂₃H₂₅N₅O₂
• 分子量: 403.5
• InChiKey: DEFAKPKFXYITPZ-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Amide-based compounds, production, recovery, purification and uses thereof
  申请人：——

  公开号：US20040059108A1

  公开（公告）日：2004-03-25

  Methods are disclosed of producing and purifying at least one amide. In accordance with one of the methods disclosed herein, the at least one amide is produced by providing an organic liquid comprising at least one oxime, providing at least one catalyst, adding the at least one catalyst to the organic liquid to form a rearrangement mass, wherein the rearrangement mass comprises at least one amide, at least one impurity, and the at least one catalyst, and heating the rearrangement mass to a temperature of at least about 115° C. for a period of time in order to sulfonate, break down and/or reduce the concentration of some of the at least one impurity in the rearrangement mass.

  本公开了生产和纯化至少一种酰胺的方法。根据本文披露的方法之一，至少一种酰胺通过提供含有至少一种肟的有机液体，提供至少一种催化剂，将至少一种催化剂加入有机液体中形成重排物质，其中重排物质包括至少一种酰胺、至少一种杂质和至少一种催化剂，并将重排物质加热至至少约115°C的温度一段时间，以磺化、分解和/或减少重排物质中至少一种杂质的浓度。
• Solid phase test for the detection of periodontal disease in subgingival plaque
  申请人：Loesche, Walter J.

  公开号：EP0380932A2

  公开（公告）日：1990-08-08

  Subgingival plaque samples can be analyzed for the presence of the trypsin substrate N-benzoyl-DL-arginine-2-naphthylamide (BANA) in order to make a clinical diagnosis of periodontal disease. The solid phase test utilizes enzyme sensitive reagents adsorbed separately onto two elements. The sample is added to one element, the second element contacted therewith and water is added to initiate the reaction. The resulting analysis is complete within thirty minutes. Positive tests indicating periodontal disease-causing organisms are determined by a color change on the element containing the Fast Black K salt color developer. The test provides a stable, readable, permanent record which can be included in the patient's dental records.

  通过分析龈下牙菌斑样本中是否含有胰蛋白酶底物 N-苯甲酰基-DL-精氨酸-2-萘甲酰胺（BANA），可以对牙周病做出临床诊断。固相检测利用分别吸附在两个元件上的酶敏感试剂。在一个元件上加入样本，第二个元件与之接触，然后加水启动反应。结果分析可在 30 分钟内完成。通过含有快速黑色 K 盐显色剂的试剂上的颜色变化来确定牙周病致病微生物的阳性检测结果。该测试可提供稳定、可读的永久记录，并可纳入患者的牙科记录中。
• Biological indicator
  申请人：American Sterilizer Company

  公开号：US10011843B2

  公开（公告）日：2018-07-03

  This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

  本发明涉及一种生物指示剂，其成分包括：由形成孢子的细菌组成的宿主生物；产生指示剂酶的报告基因；调控基因；以及将报告基因和调控基因插入宿主生物的载体；宿主生物的基因组中含有转座遗传因子，用于在调控基因中插入插入序列；插入序列包括转座酶、一对末端倒置重复序列和至少一个用于表达转座酶的开放阅读框。载体可被宿主生物吸收。插入序列可插入调控基因中。宿主生物可进行孢子繁殖以形成生物指示剂。本发明公开了一种使用生物指示剂的工艺和装置。
• Method for detecting Escherichia coli in a sample
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10023898B2

  公开（公告）日：2018-07-17

  A method of detecting Listeria monocytogenes. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system. The selective culture medium facilitates the growth of Listeria microorganisms. When a Listeria microorganism is detected in a sample contacted with the culture medium, the detection article is contacted with the culture medium to detect Listeria monocytogenes.

  一种检测李斯特菌的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。选择性培养基有利于李斯特菌微生物的生长。当在与培养基接触的样品中检测到李斯特菌微生物时，检测物品与培养基接触以检测单增李斯特菌。
• Method for detecting a Shigella or Cronobacter microorganism
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10619181B2

  公开（公告）日：2020-04-14

  A method of detecting a Shigella or Cronobacter microorganism. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system.

  一种检测志贺氏菌或克罗诺斯菌微生物的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。